Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CARDIOMYOCYTE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CARDIOMYOCYTE |
| Key Genes/Proteins | BMAL1 |
graph TD
CARDIOMYOCYTE["CARDIOMYOCYTE"]
style CARDIOMYOCYTE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
Ferroptosis["Ferroptosis"] -->|"involved_in"| CARDIOMYOCYTE
PS_NPs{"PS-NPs"} -->|"causes"| CARDIOMYOCYTE
Cadmium{"Cadmium"} -->|"causes"| CARDIOMYOCYTE
Canagliflozin{"Canagliflozin"} -->|"targets"| CARDIOMYOCYTE
AMPK([AMPK]) -->|"expressed in"| CARDIOMYOCYTE
NRF2([NRF2]) -->|"expressed in"| CARDIOMYOCYTE
BMAL1([BMAL1]) -->|"expressed in"| CARDIOMYOCYTE
GSH([GSH]) -.->|"inhibits"| CARDIOMYOCYTE
FERROPTOSIS([FERROPTOSIS]) -.->|"inhibits"| CARDIOMYOCYTE
SIRT3([SIRT3]) -.->|"inhibits"| CARDIOMYOCYTE| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| GJA1-20k | expressed_in | protein | 0.95 |
| ALOX15 | expressed_in | gene | 0.90 |
| 15-HPETE | promotes_ferroptosis | compound | 0.90 |
| Ferroptosis | involved_in | process | 0.87 |
| HIF2A | expressed_in | gene | 0.85 |
| Canagliflozin | targets | drug | 0.80 |
| Cadmium | causes | drug | 0.80 |
| PS-NPs | causes | drug | 0.80 |
| AMPK | expressed_in | protein | 0.75 |
| NRF2 | expressed_in | gene | 0.75 |
| BMAL1 | expressed_in | protein | 0.72 |
| FERROPTOSIS | inhibits | gene | 0.60 |
| SIRT3 | inhibits | gene | 0.60 |
| NRF2 | inhibits | gene | 0.60 |
| GSH | inhibits | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| ACTN2 | activates | gene | 0.60 |
| FGF21 | associated_with | gene | 0.60 |
| ALOX15 | activates | gene | 0.60 |
| GAIN | therapeutic_target | gene | 0.60 |
| AGO2 | inhibits | gene | 0.60 |
| ATP | causes | gene | 0.60 |
| MITOPHAGY | causes | gene | 0.60 |
| EXERCISE | associated_with | gene | 0.60 |
| CKB | associated_with | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| CHK1 | inhibits | gene | 0.60 |
| PGC1A | activates | gene | 0.60 |
| APOPTOSIS | causes | gene | 0.60 |
| STAT3 | activates | gene | 0.60 |
| AUTOPHAGY | causes | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| AGING | activates | gene | 0.60 |
| MITOCHONDRIA | causes | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| MITOCHONDRIA | inhibits | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
| RS7529220 | associated_with | gene | 0.60 |
| ASTROCYTES | activates | gene | 0.60 |
| PLEC | activates | gene | 0.60 |
| C1Q | associated_with | gene | 0.60 |
| FERROPTOSIS | regulates | gene | 0.60 |
| NOTCH1 | therapeutic_target | gene | 0.60 |
| BCL2 | inhibits | gene | 0.60 |
| MICRORNAS | activates | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| CCND1 | inhibits | gene | 0.60 |
| ERK | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CARDIOMYOCYTE in their description or question text
No additional research found