gene

THBS4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about THBS4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

14Outgoing

4Incoming

0Experiments

0Debates

Summary

Comprehensive information about THBS4 (Thrombospondin 4), an extracellular matrix glycoprotein involved in synaptic plasticity, neuronal survival, and neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	THBS4
Full Name	Thrombospondin 4
Chromosome	5q13.2
Function	is a secreted protein that
Primary Expression	the nervous system and plays unique roles in neural circuit formation and maintenance [@born2017]
Molecular Weight	110 kDa
Amino Acids	870 aa
Exons	22
Pathways	Wnt
UniProt ID	[P35443](https://www.uniprot.org/uniprot/P35443)
Ensembl ID	ENSG00000113205
GeneCards	THBS4
Human Protein Atlas	THBS4
Chromosomal location	5q13.2
Genomic size	~16 kb
Associated Diseases	neurodegeneration
Interactions	Cytokine, CYTOKINES, Egfr, EGFR, MYC, P53
KG Connections	18 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

THBS4 Gene

gene · 1940 words

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Pathway Diagram

flowchart TD
    N0["THBS4"]
    N1["Diabetes"]
    N0 -->|"activates"| N1
    N2["Fibrosis"]
    N0 -->|"activates"| N2
    N3["Cardiomyopathy"]
    N0 -->|"activates"| N3
    N4["Als"]
    N0 -->|"activates"| N4
    N5["TNF"]
    N0 -->|"activates"| N5
    N6["TGFB1"]
    N0 -->|"activates"| N6
    N7["EGFR"]
    N0 -->|"activates"| N7
    N8["CYTOKINES"]
    N0 -->|"activates"| N8
    N9["Wnt"]
    N0 -->|"activates"| N9
    N10["Fibroblast"]
    N0 -->|"encodes"| N10
    N11["Cardiomyocyte"]
    N0 -->|"activates"| N11
    N12["Egfr"]
    N0 -->|"activates"| N12
    N13["P53"]
    N0 -->|"activates"| N13
    N14["Cytokine"]
    N0 -->|"activates"| N14

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 disease
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 pathway
    class N12 protein
    class N13 protein
    class N14 protein

Outgoing (14)

Target	Relation	Type	Str
Cardiomyopathy	activates	disease	0.65
Als	activates	disease	0.65
Diabetes	activates	disease	0.65
Fibrosis	activates	disease	0.65
Egfr	activates	protein	0.60
P53	activates	protein	0.60
CYTOKINES	activates	gene	0.60
Cytokine	activates	protein	0.60
Wnt	activates	pathway	0.60
Fibroblast	encodes	cell_type	0.60
Cardiomyocyte	activates	cell_type	0.60
TNF	activates	gene	0.60
TGFB1	activates	gene	0.60
EGFR	activates	gene	0.60

Incoming (4)

Source	Relation	Type	Str
SMAD3	activates	gene	0.60
MYC	activates	gene	0.60
LOX	encodes	gene	0.60
P53	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning THBS4 in their description or question text

No additional research found