concept

HIF2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIF2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

25Outgoing

16Incoming

0Experiments

0Debates

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💡 Concept Info

Name	HIF2A
Key Genes/Proteins	AND, App, AREG, BANG, BMAL1, CANCER
Related Diseases	Cancer, Cardiac, ccRCC, Ms
Related Pathways	Hypoxia Response

Pathway Diagram

graph TD
    HIF2A["HIF2A"]
    HIF2A -->|"modulates"| Myocardial_Injury["Myocardial Injury"]
    HIF2A -->|"regulates"| Circadian_Rhythm["Circadian Rhythm"]
    HIF2A -->|"mediates"| Hypoxia_Response["Hypoxia Response"]
    HIF2A -->|"regulates"| Cancer["Cancer"]
    HIF2A -->|"interacts"| Ms["Ms"]
    HIF2A -->|"regulates"| Cardiac["Cardiac"]
    BMAL1["BMAL1"] -->|"binds"| HIF2A
    DNA["DNA"] -->|"interacts"| HIF2A
    BANG["BANG"] -->|"regulates"| HIF2A
    AREG["AREG"] -->|"regulates"| HIF2A
    CANCER["CANCER"] -->|"regulates"| HIF2A

Outgoing (25)

Target	Relation	Type	Str
Myocardial Injury	modulates	phenotype	0.95
Circadian Rhythm	regulates	process	0.90
Myocardial Injury	involved_in	disease	0.88
Heart	expressed_in	cell_type	0.85
cardiomyocyte	expressed_in	cell_type	0.85
Myocardial Injury	regulates	disease	0.85
myocardial injury	modulates	disease	0.80
Hypoxia Response	mediates	pathway	0.80
ccRCC	associated_with	disease	0.80
ccRCC	markers	disease	0.80
myocardial_injury	modulates	disease	0.70
Ms	interacts_with	disease	0.65
Cardiac	regulates	disease	0.65
Pain	regulates	disease	0.65
Cancer	regulates	disease	0.65
BMAL1	regulates	gene	0.60
Circadian Rhythm	interacts_with	pathway	0.60
BANG	regulates	gene	0.60
CANCER	regulates	gene	0.60
AND	activates	gene	0.60
AREG	therapeutic_target	gene	0.60
Rb	regulates	protein	0.60
App	regulates	protein	0.60
oxidative stress response	participates_in	pathway	0.60
MYOCARDIAL_INJURY	regulates	phenotype	0.56

Incoming (16)

Source	Relation	Type	Str
BMAL1	associated_with	gene	0.90
MTOR	associated_with	gene	0.85
mTOR	activates	gene	0.80
BMAL1	interacts_with	protein	0.72
MTOR	activates	gene	0.70
PCDHGC3	inhibits	gene	0.70
mTOR	targets	gene	0.70
BMAL1	activates	gene	0.60
BMAL1	targets	gene	0.60
BMAL1	regulates	gene	0.60
DNA	interacts_with	gene	0.60
BANG	regulates	gene	0.60
AREG	regulates	gene	0.60
AREG	associated_with	gene	0.60
AREG	targets	gene	0.60
CANCER	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HIF2A in their description or question text

No additional research found