Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about APOD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | APOD |
| Key Genes/Proteins | ABCA1, ABCA2, ABCB1, AGING, ALZHEIMER, ALZHEIMER'S DISEASE |
| Related Diseases | Aging, Als, ALS, Alzheimer |
graph TD
APOD["APOD"]
APOD -->|"regulates"| Alzheimer["Alzheimer"]
APOD -->|"regulates"| Als["Als"]
APOD -->|"regulates"| Atherosclerosis["Atherosclerosis"]
APOD -->|"transports"| ALS["ALS"]
RPS18["RPS18"] -->|"downregulates"| APOD
CH25H["CH25H"] -->|"activates"| APOD
LRP8["LRP8"] -->|"activates"| APOD
APOA1["APOA1"] -->|"activates"| APOD
MAPT["MAPT"] -->|"regulates"| APOD
LRP1["LRP1"] -->|"activates"| APOD
LIPA["LIPA"] -->|"regulates"| APOD
ALZHEIMER["ALZHEIMER"] -->|"regulates"| APOD| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | degrades | disease | 0.65 |
| Als | degrades | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Atherosclerosis | regulates | disease | 0.65 |
| Atherosclerosis | degrades | disease | 0.65 |
| Atherosclerosis | transports | disease | 0.65 |
| Alzheimer | transports | disease | 0.65 |
| ALS | transports | disease | 0.65 |
| APOA1 | activates | gene | 0.60 |
| TFCP2 | degrades | gene | 0.60 |
| LIPA | degrades | gene | 0.60 |
| Tau | degrades | protein | 0.60 |
| App | degrades | protein | 0.60 |
| MYELIN | regulates | gene | 0.60 |
| Ras | regulates | protein | 0.60 |
| APOE | activates | gene | 0.60 |
| lipid metabolism | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| COL4A1 | activates | gene | 0.60 |
| INSR | activates | gene | 0.60 |
| PDGFRB | activates | gene | 0.60 |
| SLC6A1 | activates | gene | 0.60 |
| pericytes | expressed_in | cell_type | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| neurodegeneration | protects_against | process | 0.60 |
| GSK3B | regulates | gene | 0.60 |
| PSEN1 | regulates | gene | 0.60 |
| SREBF1 | regulates | gene | 0.60 |
| APOC1 | activates | gene | 0.60 |
| TFCP2 | regulates | gene | 0.60 |
| APOC2 | activates | gene | 0.60 |
| SOAT1 | activates | gene | 0.60 |
| ABCA2 | activates | gene | 0.60 |
| PSEN2 | regulates | gene | 0.60 |
| TAU | regulates | gene | 0.60 |
| LDLR | activates | gene | 0.60 |
| APOC3 | activates | gene | 0.60 |
| Cholesterol | activates | pathway | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| ASTROCYTES | regulates | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| Oxidative Stress | regulates | pathway | 0.60 |
| Astrocyte | regulates | cell_type | 0.60 |
| TAU | transports | gene | 0.60 |
| GENES | transports | gene | 0.60 |
| APOC1 | transports | gene | 0.60 |
| ALZHEIMER | transports | gene | 0.60 |
| LRP1 | transports | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RPS18 | downregulates | gene | 0.80 |
| CH25H | activates | gene | 0.60 |
| LRP8 | activates | gene | 0.60 |
| APOA1 | activates | gene | 0.60 |
| MAPT | regulates | gene | 0.60 |
| LRP1 | activates | gene | 0.60 |
| LIPA | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| APP | regulates | gene | 0.60 |
| APOE | activates | gene | 0.60 |
| CYP46A1 | activates | gene | 0.60 |
| ABCA1 | activates | gene | 0.60 |
| NCSTN | regulates | gene | 0.60 |
| MYELIN | regulates | gene | 0.60 |
| APOE | transports | gene | 0.60 |
| NCSTN | transports | gene | 0.60 |
| PSEN2 | transports | gene | 0.60 |
| LIPA | transports | gene | 0.60 |
| LDLR | transports | gene | 0.60 |
| TFCP2 | transports | gene | 0.60 |
| ABCA1 | transports | gene | 0.60 |
| GSK3B | transports | gene | 0.60 |
| LRP8 | transports | gene | 0.60 |
| APOA1 | transports | gene | 0.60 |
| CYP46A1 | transports | gene | 0.60 |
| SOAT1 | transports | gene | 0.60 |
| APP | transports | gene | 0.60 |
| MAPT | transports | gene | 0.60 |
| ABCA2 | transports | gene | 0.60 |
| AND | transports | gene | 0.60 |
| ALZHEIMER'S DISEASE | transports | gene | 0.60 |
| PSEN1 | transports | gene | 0.60 |
| CH25H | transports | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| OXIDATIVE STRESS | regulates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| ASTROCYTES | regulates | gene | 0.60 |
| APOC3 | activates | gene | 0.60 |
| APP | degrades | gene | 0.60 |
| PSEN2 | degrades | gene | 0.60 |
| MAPT | degrades | gene | 0.60 |
| ALZHEIMER | degrades | gene | 0.60 |
| SREBF1 | degrades | gene | 0.60 |
| NCSTN | degrades | gene | 0.60 |
| PSEN1 | degrades | gene | 0.60 |
| LDLR | activates | gene | 0.60 |
| APOC1 | activates | gene | 0.60 |
| SOAT1 | activates | gene | 0.60 |
| ABCA2 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning APOD in their description or question text
No additional research found