concept

MEMORY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEMORY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

12Hypotheses

1Analyses

1Outgoing

47Incoming

10Experiments

1Debates

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💡 Concept Info

Name	MEMORY
Key Genes/Proteins	BDNF, CYP46A1, GD3 synthase, IGF2, M1_RECEPTOR
Related Diseases	EXERCISE, LTP

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Bruce L. Miller — Director of UCSF Memory and Aging Center

researcher · 1869 words

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Pathway Diagram

graph TD
    MEMORY["MEMORY"]
    IGF2["IGF2"] -->|"modulates"| MEMORY
    Caffeine["Caffeine"] -->|"modulates"| MEMORY
    GSK3__["GSK3-beta"] -->|"regulates"| MEMORY
    EXERCISE["EXERCISE"] -->|"activates"| MEMORY
    Alzheimer_s_disease["Alzheimer's disease"] -->|"causes"| MEMORY
    Hippocampus["Hippocampus"] -->|"activates"| MEMORY
    BDNF["BDNF"] -->|"regulates"| MEMORY

Outgoing (1)

Target	Relation	Type	Str
Synaptic Autophagy	associated_with	process	0.85

Incoming (47)

Source	Relation	Type	Str
hippocampus	involved_in	brain_region	0.95
IGF2	associated_with	protein	0.95
IGF2	regulates	gene	0.95
FB23	associated_with	drug	0.90
BDNF	promotes	gene	0.90
Glp1 Receptor Agonists	associated_with	drug	0.90
Mch Neurons	mediates	cell_type	0.90
ST8SIA1	regulates	gene	0.90
IGF2	upregulates	protein	0.90
Hcrtr2	regulates	protein	0.85
PSN1	contributes_to	protein	0.85
PKN1-N207	associated_with	protein	0.85
Caffeine	modulates	compound	0.85
Brain Amyloid-Beta Reduction	associated_with	process	0.85
Hdac3 Inhibition	associated_with	mechanism	0.85
Gamma-Secretase Complex	involved_in	enzyme	0.80
Oveporexton	associated_with	drug	0.80
Neurodegenerative Diseases	causes	disease	0.80
CLU	modulates	protein	0.80
GSK3-β	regulates	enzyme	0.80
GD3 synthase	improves	gene	0.80
IGF2	enhances	gene	0.80
BDNF	associated_with	protein	0.80
Ginsenoside Rg1	regulates	compound	0.75
Rehmannia glutinosa Libosch	associated_with	compound	0.75
Unfolded Protein Response	associated_with	pathway	0.75
SNCA	involved_in	protein	0.75
EXERCISE	activates	phenotype	0.72
Alzheimer's disease	causes	disease	0.70
BDNF	enhances	gene	0.70
Hippocampus	activates	entity	0.70
Rapamycin	improves	drug	0.70
Gastrodin	promotes	compound	0.70
PTN	activates	protein	0.70
BDNF	regulates	protein	0.70
Gastrodin	protects_against	compound	0.70
BDNF	activates	protein	0.68
LTP	regulates	phenotype	0.68
M1_RECEPTOR	regulates	protein	0.64
PVALB	involved_in	protein	0.60
HDAC3	regulates	protein	0.60
PTK2B	involved_in	gene	0.60
39559873	had positive impact on	paper	0.60
39559873	showed positive impact on	paper	0.60
CYP46A1	protects_against	gene	0.60
15483599	could depend on	paper	0.60
15483599	depends on	paper	0.60

Targeting Hypotheses (12)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Alpha-gamma cross-frequency coupling enhancement to restore	0.775	Alzheimer's disease	Circuit-level neural dynamics in neurode
Epigenetic Memory Erasure via TET2 Activation	0.741	neurodegeneration	Astrocyte reactivity subtypes in neurode
Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat	0.690	neurodegeneration	CRISPR-based therapeutic approaches for
Astrocyte-Mediated Microglial Memory Erasure	0.677	-	Neuroinflammation and microglial priming
PGE2–EP2–cAMP–PKA Axis Displaces Pathological Microglial Mem	0.649	neuroinflammation	What specific astrocyte-derived factors

Epigenetic Reprogramming of Microglial Memory	0.647	Alzheimer's disease	Neuroinflammation and microglial priming
Astrocyte Metabolic Memory Reprogramming	0.646	neurodegeneration	How do astrocyte-neuron metabolic intera
Epigenetic Memory Reprogramming for Alzheimer's Disease	0.611	neurodegeneration	CRISPR-based therapeutic approaches for
Astrocyte-Derived EV miR-146a-5p Mimics as Erasers of Traine	0.563	neuroinflammation	What specific astrocyte-derived factors
ApoE4-Mediated Failure of Cholesterol Efflux as Memory Maint	0.490	neuroinflammation	What specific astrocyte-derived factors
HBOT at 2.0 ATA for 60 min, 5x/week for 6 weeks enhances hip	0.450	neurodegeneration	What are the optimal oxygen pressure, du
STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine	0.370	immunomics	Systemic immune profiling in neurodegene

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 7 hypotheses Top: 0.680

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Tet2 modulation in Aβ42-injured mouse hippocampal neurons	exploratory	Alzheimer's disease	0.900	0.00	primary mouse hippocampal neur	proposed	N/A
AAV-mediated Tet2 modulation in 2×Tg-AD mice behavioral study	validation	Alzheimer's disease	0.900	0.00	young APPswe/PSEN1 double-tran	proposed	N/A
Acteoside treatment in LPS-induced SALI mouse model	validation	sepsis-associated acute lung i	0.900	0.00	LPS-induced SALI mouse model	proposed	N/A
Tet2 expression analysis in aged 2×Tg-AD mouse brains	exploratory	Alzheimer's disease	0.850	0.00	APPswe/PSEN1 double-transgenic	proposed	N/A
Nrf2 inhibitor ML385 mechanism validation experiment	exploratory	sepsis-associated acute lung i	0.850	0.00	RAW264.7 cells and/or mouse mo	proposed	N/A
Acteoside effects on RAW264.7 macrophage cells	exploratory	sepsis-associated acute lung i	0.850	0.00	RAW264.7 cells	proposed	N/A
Single-cell RNA sequencing of microglial states in AD hippocampus	exploratory	Alzheimer's disease	0.850	0.00	AD mouse hippocampus	proposed	N/A
Morphological characterization of microglial states in human brain	exploratory	Alzheimer's disease	0.800	0.00	human brain tissue	proposed	N/A
Proposed experiment from debate on Epigenetic clocks and biological ag	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$450,000
CRISPR Gene Correction Approaches for CBS/PSP	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated [PMID:40929507]	Koh Y, Tengesdal IW, Jaiswal S	Annu Rev Pathol	2026	1
Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression a [PMID:40752494]	Liu Z, Zhang S, James BT, Galani K, Mang	Cell	2025	1
Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical [PMID:38678292]	Oosthoek M, Vermunt L, de Wilde A, Bonge	Alzheimer's research & therapy	2024	1
TET2 guards against unchecked BATF3-induced CAR T cell expansion. [PMID:36755094]	Jain N, Zhao Z, Feucht J, Koche R, Iyer	Nature	2023	1
Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Futur [PMID:36928826]	Singh I, Singh A	Curr Oncol Rep	2023	1
Detailed stratified GWAS analysis for severe COVID-19 in four European populatio [PMID:35848942]	Degenhardt F, Ellinghaus D, Juzenas S, L	Human molecular genetics	2022	1
The function and regulation of TET2 in innate immunity and inflammation. [PMID:33085059]	Cong B, Zhang Q, Cao X	Protein Cell	2021	1
Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Hom [PMID:29548672]	Datta M, Staszewski O, Raschi E, Frosch	Immunity	2018	1
Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines [PMID:26746105]	Herbert J, Lucassen PJ	Frontiers in neuroendocrinolog	2016	1
Global epigenomic reconfiguration during mammalian brain development. [PMID:23828890]	Lister R, Mukamel EA, Nery JR, Urich M,	Science	2013	1
TET1 deficiency amplifies macrophage inflammatory signaling associated with Croh [PMID:41896302]	["Perez R", "Paul R", "Kumar P", "Tutkun	Inflammation research : offici	2026	0
Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042]	["Lyu G", "Li D"]	CNS & neurological disorders d	2026	0
Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pa [PMID:41811389]	Liu K, Hong Y, Gao Q, Huang J, Liu L, Li	Cellular and molecular life sc	2026	0
Clonal Hematopoiesis in Cardiovascular Risk: Focus on Inflammatory Mechanisms. [PMID:41899316]	["Sinnadurai S", "Honigberg M", "Meijers	Journal of clinical medicine	2026	0
Clonal Hematopoiesis and Risk of Trastuzumab-Related Cardiotoxic Effects. [PMID:41926089]	Park CS, Ryu G, Ahn HJ, Sun C, Lee SP, K	JAMA oncology	2026	0
Chimeric antigen receptor T-cell therapies related to immune effector cell-assoc [PMID:41914034]	Zhang Y, Yang J, Xin H, Ai K, Yang M, Li	Chinese medical journal	2026	0
Targeting synaptic plasticity and acetylcholine dysregulation in the medial pref [PMID:41014339]	Shi J, Chen M, Zhang Y, Fan X, Wang L et	Psychopharmacology (Berl)	2026	0
Obstructive sleep apnea, biomarker profiles, and clinical progression in Parkins [PMID:41499940]	Zhu S, An D, Liu X	Sleep Med	2026	0
Systemic inflammation and its associations in acute moderate-severe Traumatic Br [PMID:41623670]	Li LM, Kodosaki E, Xu CJY, Heslegrave A,	Brain Behav Immun Health	2026	0
Time-dependent neurovascular unit dysfunction in ischemic stroke: mechanisms of [PMID:41642667]	Lahariya R, Sinha M, Kumari B, Subramani	Int J Neurosci	2026	0

Debates (1)

Multi-agent debates referencing this entity

Lysosomal membrane permeabilization releasing cathepsins triggers NLRP3 inflamma

closed · Rounds: 4 · Score: 0.76 · 2026-04-22

Related Research

Hypotheses and analyses mentioning MEMORY in their description or question text

Epigenetic Reprogramming of Microglial Memory

Score: 0.647 · Alzheimer's disease · 2026-04-04

## Mechanistic Overview Epigenetic Reprogramming of Microglial Memory starts from the claim that modulating DNMT3A, HDAC

Astrocyte Metabolic Memory Reprogramming

Score: 0.646 · neurodegeneration · 2026-04-12

## Mechanistic Overview Astrocyte Metabolic Memory Reprogramming starts from the claim that modulating SIRT1 within the

Epigenetic Memory Reprogramming for Alzheimer's Disease

Score: 0.611 · neurodegeneration · 2026-04-02

## Mechanistic Overview Epigenetic Memory Reprogramming for Alzheimer's Disease starts from the claim that modulating BD

Astrocyte-Derived EV miR-146a-5p Mimics as Erasers of Trained Microglial NF-κB M

Score: 0.563 · neuroinflammation · 2026-04-26

AEVs containing miR-146a-5p are taken up by microglia and suppress IRAK1/TRAF6, disrupting sustained NF-κB activation th

ApoE4-Mediated Failure of Cholesterol Efflux as Memory Maintenance Mechanism

Score: 0.490 · neuroinflammation · 2026-04-26

Incomplete hypothesis (truncated). ApoE4 isoform from astrocytes fails to mediate proper cholesterol efflux from microgl

HBOT at 2.0 ATA for 60 min, 5x/week for 6 weeks enhances hippocampal neurogenesi

Score: 0.450 · neurodegeneration · 2026-04-25

HBOT increases cerebral oxygen tension, creating a favorable microenvironment for NSC proliferation and upregulating BDN

STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine Memory

Score: 0.370 · immunomics · 2026-04-25

STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine Memory