gene

tmx2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about tmx2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

61Connections

0Hypotheses

0Analyses

44Outgoing

17Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	TMX2
Protein Type	Gene
Function	The protein's topology places its redox-active domain in the ER lumen, where it can interact with other ER-resident proteins involved in disulfide bond formation and protein folding.
Subcellular Localization	the endoplasmic reticulum (ER) membrane, where it participates in ER redox homeostasis and protein quality control mecha
Molecular Weight	32 kDa
Pathways	Autophagy, Oxidative Stress, Mitophagy, CRISPR-Cas, autophagy pathway
GeneCards	TMX2
Human Protein Atlas	TMX2
Associated Diseases	Hepatocellular Carcinoma, Poor Prognosis
Interactions	GAIN, PRKN, Proteins, TFEB, VDAC2
KG Connections	11 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

tmx2

gene · 1828 words

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Pathway Diagram

graph TD
    TMX2["TMX2"]
    TMX2 -->|"promotes"| macroautophagy["macroautophagy"]
    TMX2 -->|"promotes_nuclear_import_of"| TFEB["TFEB"]
    TMX2 -->|"modulates"| KPNB1["KPNB1"]
    TMX2 -->|"promotes"| hepatocellular_carcinoma["hepatocellular carcinoma"]
    TMX2 -->|"interacts"| VDAC3["VDAC3"]
    TMX2 -->|"promotes"| mitophagy["mitophagy"]
    oxidative_stress["oxidative stress"] -->|"regulates"| TMX2
    Oxidative_Stress["Oxidative Stress"] -->|"upregulates"| TMX2
    MITOPHAGY["MITOPHAGY"] -->|"activates"| TMX2
    MITOCHONDRIA["MITOCHONDRIA"] -->|"interacts"| TMX2
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| TMX2
    TFEB -->|"activates"| TMX2
    GENES["GENES"] -->|"activates"| TMX2

Outgoing (44)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:TMX2	data_in	dataset_row	0.00
macroautophagy	promotes	process	0.95
Hepatocellular Carcinoma	associated_with	disease	0.95
TFEB	promotes_nuclear_import_of	protein	0.95
Poor Prognosis	associated_with	phenotype	0.90
KPNB1	modulates	protein	0.90
TFEB	modulates	protein	0.90
KPNB1	facilitates_nuclear_export_of	protein	0.90
hepatocellular carcinoma	promotes	disease	0.90
VDAC3	interacts_with	protein	0.87
PRKN	mediates	protein	0.85
mitophagy	promotes	process	0.85
AUTOPHAGY	promotes	process	0.80
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
OXIDATIVE STRESS	activates	gene	0.60
TFEB	transports	gene	0.60
oxidative stress response	participates_in	pathway	0.60
Autophagy	activates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
MITOPHAGY	activates	gene	0.60
GENES	activates	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
VDAC2	interacts_with	gene	0.60
GAIN	activates	gene	0.60
PRKN	interacts_with	gene	0.60
TFEB	activates	gene	0.60
AND	activates	gene	0.60
CRISPR-Cas	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
VDAC2	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
GAIN	activates	gene	0.50
MITOCHONDRIA	activates	cell_type	0.50
PRKN	activates	gene	0.50
VDAC2	activates	protein	0.50
oxidative stress	activates	phenotype	0.50
Autophagy	activates	process	0.50
mitophagy	activates	pathway	0.50
CARCINOMA	activates	disease	0.50
HEPATOCELLULAR CARCINOMA	activates	disease	0.50
Proteins	activates	protein	0.50

Incoming (17)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:TMX2	data_in	dataset_row	0.00
oxidative stress	upregulates	process	0.85
Oxidative Stress	upregulates	process	0.85
oxidative stress	regulates	phenotype	0.85
GENES	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
AND	activates	gene	0.60
HUMAN GENES	activates	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
PRKN	interacts_with	gene	0.60
GAIN	activates	gene	0.60
VDAC2	interacts_with	gene	0.60
PRKN	activates	gene	0.60
TFEB	activates	gene	0.60
TFEB	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning tmx2 in their description or question text

No additional research found