gene

ABCA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1167Connections

4Hypotheses

5Analyses

50Outgoing

50Incoming

1Experiments

5Debates

Summary

ABCA1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with AD, ALS, AMI. Connected to 280 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	ABCA1
Full Name	ATP-Binding Cassette Transporter A1
Chromosome	9q31.1
Protein Type	Transporter
Target Class	Transporter
Function	is a full-size ABC transporter with a classic architecture
Mechanism of Action	Small molecule modulators to enhance cholesterol efflux and HDL formation
Primary Expression	Brain (astrocytes, microglia, neurons), liver, macrophages, intestine
Druggability	Medium (0.47)
Clinical Stage	Approved
Molecular Weight	~270 kDa
Amino Acids	2,461 amino acids
Exons	50
Pathways	Cholesterol, Epigenetic, Lipid Metabolism, Microrna, Mitochondrial Function
UniProt ID	O95477
NCBI Gene ID	19
Ensembl ID	ENSG00000165029
GeneCards	ABCA1
Human Protein Atlas	ABCA1
Associated Diseases	Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	25-Hydroxycholesterol, dexamethasone, quercetin, statins
Interactions	4E-BP1, abca2, ABCA2, ABCA4, ABCA7, ABCG1
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	HDL/apoE Particle Remodeling as a Therapeutic Swit APOE4 hypolipidation and ABCA1 mistrafficking impa
KG Connections	1163 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — ABCA1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

7TBJ — X-ray / Cryo-EM

🔮 AI Predicted Structure

O95477 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ABCA1["ABCA1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    ABCA1["ABCA1"] -->|"interacts"| LDLR["LDLR"]
    ABCA1["ABCA1"] -->|"interacts"| SREBF2["SREBF2"]
    ABCA1["ABCA1"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ABCA1["ABCA1"] -->|"interacts"| Als["Als"]
    ABCA1["ABCA1"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    h_9d29bfe5["h-9d29bfe5"] -->|"targets"| ABCA1["ABCA1"]
    LDLR_1["LDLR"] -->|"interacts"| ABCA1["ABCA1"]
    SREBF2_2["SREBF2"] -->|"interacts"| ABCA1["ABCA1"]
    ACTB["ACTB"] -->|"interacts"| ABCA1["ABCA1"]
    style ABCA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (850)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCA1	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:ABCA1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
APOE	associated_with	gene	0.90
Lipid Efflux	promotes	process	0.90
Tau Pathology	suppresses	phenotype	0.90
Glial Lipid Accumulation	suppresses	phenotype	0.90
lipid efflux	regulates	process	0.85
cholesterol homeostasis	participates_in	pathway	0.85
Cholesterol Efflux	mediates	process	0.85
Reverse Cholesterol Transport	participates_in	pathway	0.80
senescence	participates_in	pathway	0.80
APOE	activates	gene	0.80
ALZHEIMER'S DISEASE	associated_with	disease	0.75
Cancer	associated_with	disease	0.75
Atherosclerosis	activates	disease	0.75
Atherosclerosis	inhibits	disease	0.75
Tumor	activates	disease	0.75
Als	activates	disease	0.75
MICROGLIA	expressed_in	cell_type	0.70
TFEB	regulates	gene	0.70
NEURONS	expressed_in	cell_type	0.70
ENDOTHELIAL	interacts_with	cell_type	0.70
APOE	expressed_in	gene	0.70
ASTROCYTE	activates	cell_type	0.70
TARDBP	inhibits	gene	0.70
OLIGODENDROCYTE	associated_with	cell_type	0.70
STING	associated_with	gene	0.70
NEP	associated_with	gene	0.70
ASTROCYTE	associated_with	cell_type	0.70
ASTROCYTE	expresses	cell_type	0.70
LDLR	protects_against	gene	0.70
LDLR	expressed_in	gene	0.70
NEURONS	associated_with	cell_type	0.70
OLIGODENDROCYTE	expresses	cell_type	0.70
LDLR	targets	gene	0.70
STING	expresses	gene	0.70
APP	expressed_in	gene	0.70
CYP46A1	expressed_in	gene	0.70
OLIGODENDROCYTES	expresses	cell_type	0.70
APOE	targets	gene	0.70
RAGE	transports	gene	0.70
OLIGODENDROCYTE	activates	cell_type	0.70
OLIGODENDROCYTES	activates	cell_type	0.70
SIRT6	activates	gene	0.70
SIRT1	interacts_with	gene	0.70
GPX4	transports	gene	0.70
APOE	enhances	gene	0.70
Mtor	inhibits	pathway	0.70
neural stem cells	regulates	cell_type	0.70

Incoming (317)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCA1	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:ABCA1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
genes-abcab1	linked_to	wiki_page	1.00
genes-abca1	describes	wiki_page	0.95
h-64d92165	targets_gene	hypothesis	0.90
TNF	downregulates	protein	0.90
h-9d29bfe5	targets	hypothesis	0.90
25-Hydroxycholesterol	modulates	compound	0.85
ALZHEIMER DISEASE	associated_with	gene	0.80
SPP1	suppresses	gene	0.75
PI3K	inhibits	gene	0.70
HDAC3	regulates	gene	0.70
HDAC3	treats	gene	0.70
EGFR	inhibits	gene	0.70
LXRα	upregulates	transcription_factor	0.70
NEURONS	regulates	cell_type	0.70
ABCA7	interacts_with	protein	0.70
HDAC3	inhibits	gene	0.70
ROS	activates	phenotype	0.70
AKT	inhibits	gene	0.70
LDLR	interacts_with	gene	0.68
SREBF2	interacts_with	gene	0.68
OSTEOBLASTS	regulates	cell_type	0.65
MACROPHAGES	activates	cell_type	0.65
MACROPHAGES	inhibits	cell_type	0.65
ISCHEMIA	activates	disease	0.65
SENESCENCE	regulates	phenotype	0.65
NLRP3 INFLAMMASOME	treats	pathway	0.65
P2RY12	treats	gene	0.65
P62	interacts_with	gene	0.60
TFEB	therapeutic_target	gene	0.60
BECLIN1	activates	gene	0.60
SQSTM1	activates	gene	0.60
LAMP1	activates	gene	0.60
P62	activates	gene	0.60
CD68	activates	gene	0.60
PSMB5	contributes_to	gene	0.60
PARK7	contributes_to	gene	0.60
CASP4	contributes_to	gene	0.60
GNB5	contributes_to	gene	0.60
SNCA	contributes_to	gene	0.60
PLIN2	activates	gene	0.60
SOAT1	activates	gene	0.60
dexamethasone	activates	compound	0.60
dexamethasone	regulates	compound	0.60
NORMAL TENSION GLAUCOMA	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA	0.766	neurodegeneration	What molecular mechanisms explain how ap
APOE4 astrocytes exhibit impaired cholesterol efflux via ABC	0.760	neuroscience	APOE4-driven lipid metabolism dysregulat
Selective LXRβ agonists restore ABCA1/ABCG1 expression and A	0.710	neuroscience	APOE4-driven lipid metabolism dysregulat
APOE4 hypolipidation and ABCA1 mistrafficking impair cholest	0.680	molecular biology	Does APOE4's reduced lipid-binding direc

Mentioning Analyses (5)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
ABCA1 rs2230806 polymorphism association with dementia risk in hyperli	exploratory	dementia, Alzheimer's disease	0.900	0.00	human patients	proposed	N/A

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Neuroprotective Effects of Berberine Chloride Against the Aluminium Chloride-Ind [PMID:40014257]	Uvarajan D, Gnanarajan R, Karuppusamy PA	Mol Biotechnol	2026
Multimodal Antiatherosclerotic Effects of Clinical-Grade Mesenchymal Stem Cell-D [PMID:41503702]	Kim J, Park D, Yoo J, Kim JE, Kim EH et	Stroke	2026
Interplay between cholesterol, Bis(monoacylglycerol)phosphate, and parasitophoro [PMID:41747887]	Hennot C, Leroux M, Lambert R, Boukherro	Biochimie	2026
Integrated Bioinformatics Analysis of a TF-miRNA-mRNA Regulatory Network in Reti [PMID:41755728]	Liang C, Xie H, Shi Q, Diao Y, Yu G et a	Curr Eye Res	2026
ApoE4 Drives Microglial Lipid Dysregulation in Alzheimer's Disease via Epigeneti [PMID:41808104]	Lin L, Pan Z, Wei Z, Jiang X, Lai Y et a	J Neuroinflammation	2026
Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzhei [PMID:41844011]	Wu L, Dong YT, Mu X, Luo X, Chen ZJ	J Prev Alzheimers Dis	2026
Atractylenolide I mitigates Alzheimer's disease pathology in ApoE (-/-) mice via [PMID:41877626]	Zhou X, Wang R, Yan J, Wu X, Yuan D et a	Acta Biochim Biophys Sin (Shan	2026
ABCA1-Mediated Structural Diversity of HDL Subspecies and Their Proposed Roles i [PMID:41884896]	Heinecke JW, Segrest JP, Phillips MC, Da	Arterioscler Thromb Vasc Biol	2026
Transcriptomic Analysis of High and Low Lipid Droplet Deposition Subpopulations [PMID:41897862]	Wang B, Li Y, Wang Y, Chen J, Wang J et	Animals (Basel)	2026
Chicoric acid enhanced brain cholesterol efflux and reduced Aβ pathology via LXR [PMID:41934727]	Li D, Zhang Y, Wang R, Jin L, Cui X et a	Neurotherapeutics	2026
Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzhei [PMID:41844011]	Wu L, Dong YT, Mu X, Luo X, Chen ZJ	The journal of prevention of A	2026
Transcriptomic Analysis of High and Low Lipid Droplet Deposition Subpopulations [PMID:41897862]	Wang B, Li Y, Wang Y, Chen J, Wang J, Li	Animals : an open access journ	2026

Debates (5)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning ABCA1 in their description or question text

No additional research found

ABCA1

Understanding Entity Pages

Summary

Wiki Pages (4)

ABCA1 - ATP-Binding Cassette Transporter A1

ABCA1 Gene

ABCA1→Cholesterol Efflux→APOE Lipidation→Alzheimer's Disease Causal Chain

ABCA1 Protein

Pathway Diagram

Outgoing (850)

Incoming (317)

Targeting Hypotheses (4)

Mentioning Analyses (5)

Microglial subtypes in neurodegeneration — friend vs foe

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Mechanistic role of APOE in neurodegeneration

Lipid raft composition changes in synaptic neurodegeneration

Experiments (1)

Related Papers (12)

Debates (5)

Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma

The study demonstrates that apoE is absolutely required for CAA development, as

Investigate how lipid raft composition (cholesterol metabolism, sphingolipids) c

Analysis question not specified

What gene expression changes in the aging mouse brain predict neurodegenerative

Related Research