concept

CHOLESTEROL METABOLISM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHOLESTEROL METABOLISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

356Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

4Debates

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💡 Concept Info

Name	CHOLESTEROL METABOLISM
Key Genes/Proteins	ABCA1, ALZHEIMER, AMYLOID, AMYLOID-BETA, amyotrophic lateral sclerosis, APOE
Related Diseases	aging, ALS, alzheimers, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Pathway Diagram

graph TD
    CHOLESTEROL_METABOLISM["CHOLESTEROL METABOLISM"]
    CHOLESTEROL_METABOLISM -->|"involved_in"| PREIMPLANTATION_DEVELOPMENT["PREIMPLANTATION DEVELOPMENT"]
    CHOLESTEROL_METABOLISM -->|"regulates"| CD8__T_Cell_Immunity["CD8+ T Cell Immunity"]
    CHOLESTEROL_METABOLISM -->|"causes"| Macrophage_Senescence["Macrophage Senescence"]
    CHOLESTEROL_METABOLISM -->|"regulates"| INFLAMMATION["INFLAMMATION"]
    CHOLESTEROL_METABOLISM -->|"inhibits"| ERK["ERK"]
    CHOLESTEROL_METABOLISM -->|"activates"| LYSOSOME["LYSOSOME"]
    CHOLESTEROL_METABOLISM -->|"regulates"| NEURON["NEURON"]
    LDLR["LDLR"] -->|"participates in"| CHOLESTEROL_METABOLISM
    SGMS1["SGMS1"] -->|"involved_in"| CHOLESTEROL_METABOLISM
    NR1H3["NR1H3"] -->|"regulates"| CHOLESTEROL_METABOLISM
    PPARGC1A["PPARGC1A"] -->|"regulates"| CHOLESTEROL_METABOLISM
    APOE["APOE"] -->|"regulates"| CHOLESTEROL_METABOLISM
    ApoE["ApoE"] -->|"regulates"| CHOLESTEROL_METABOLISM
    AGING["AGING"] -->|"regulates"| CHOLESTEROL_METABOLISM
    ABCA1["ABCA1"] -->|"activates"| CHOLESTEROL_METABOLISM

Outgoing (62)

Target	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	0.90
Preimplantation Embryos	involved_in	cell_type	0.85
Oligodendrocyte	expressed_in	cell_type	0.85
PREIMPLANTATION DEVELOPMENT	involved_in	entity	0.85
CD8+ T Cell Immunity	regulates	process	0.85
Macrophage Senescence	causes	phenotype	0.85
Tau-Mediated Degeneration	contributes_to	process	0.80
neurodegeneration	modulates	mechanism	0.70
Alzheimer's disease	associated_with	disease	0.70
LRP1	regulates	gene	0.65
NEURON	interacts_with	cell_type	0.65
DEPRESSION	implicated_in	disease	0.55
CYP46A1	implicated_in	gene	0.55
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
Microglia	associated_with	cell_type	0.50
Neuron	associated_with	cell_type	0.50
Astrocyte	associated_with	cell_type	0.50
Macrophage	associated_with	cell_type	0.50
HUNTINGTON'S DISEASE	associated_with	disease	0.45
PARKINSON'S DISEASE	associated_with	disease	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
NEUROGENESIS	associated_with	phenotype	0.45
FRONTAL CORTEX	associated_with	brain_region	0.45
FUS	associated_with	gene	0.45
CORTEX	associated_with	brain_region	0.45
TREM2	associated_with	gene	0.45
ASTROCYTES	associated_with	cell_type	0.45
NEURODEGENERATION	associated_with	disease	0.45
AMYLOID-BETA	associated_with	protein	0.45
NEURONS	associated_with	cell_type	0.45
INFLAMMATION	associated_with	phenotype	0.45
TAU	associated_with	protein	0.45
SENESCENCE	associated_with	phenotype	0.45
LRP1	associated_with	gene	0.45
ERK	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
CERAMIDE	associated_with	phenotype	0.45
BDNF	associated_with	gene	0.45
STING	associated_with	gene	0.45
MACROPHAGES	associated_with	cell_type	0.45
IMMUNE RESPONSE	activates	process	0.35
OXIDATIVE STRESS	interacts_with	process	0.35
DEPRESSION	causes	disease	0.35
DEPRESSION	metabolizes	disease	0.35
CORTEX	activates	brain_region	0.35
GLIOBLASTOMA	implicated_in	disease	0.35
DEPRESSION	activates	disease	0.35
CORTEX	causes	brain_region	0.35
SYNAPTIC PLASTICITY	activates	process	0.35
STING	regulates	gene	0.35

Incoming (294)

Source	Relation	Type	Str
ATAD3A	regulates	protein	0.95
APOE4	modulates	protein	0.90
LDLR	participates_in	gene	0.90
SGMS1	involved_in	protein	0.88
NR1H3	regulates	entity	0.85
PPARGC1A	regulates	gene	0.80
TNFα	disrupts	protein	0.80
APOE	regulates	gene	0.70
ApoE	regulates	protein	0.70
SREBP1c modulators	modulates	drug	0.70
SREBF2	regulates	gene	0.60
MYELIN	associated_with	gene	0.60
HMGCR	regulates	gene	0.60
APOE4	activates	gene	0.60
NEURON	activates	gene	0.60
MICROGLIA	activates	gene	0.60
APOE	regulates	gene	0.60
ALZHEIMER	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
APOE	activates	gene	0.60
TAU	activates	gene	0.60
APOE3	activates	gene	0.60
TAUOPATHY	activates	gene	0.60
CYP46A1	regulates	gene	0.60
ABCA1	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
CXCL1	activates	gene	0.60
AGING	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
JUN	activates	gene	0.60
GENES	regulates	gene	0.60
DNA	regulates	gene	0.60
GAIN	regulates	gene	0.60
SREBP2	regulates	gene	0.60
IFN	regulates	gene	0.60
STING	regulates	gene	0.60
LDL	causes	gene	0.60
APP	causes	gene	0.60
ATP	causes	gene	0.60
SREBP2	causes	gene	0.60
BACE1	causes	gene	0.60
ALZHEIMER'S DISEASE	causes	gene	0.60
ABCA1	causes	gene	0.60
AMYLOID	causes	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
AMYLOID-BETA	causes	gene	0.60