gene

CD38

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD38: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

621Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

CD38 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Aging, Als. Connected to 290 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD38
Chromosome	4p15.32
Protein Type	Enzyme
Target Class	Enzyme
Function	cADPR acts as a potent second messenger that releases calcium from intracellular stores (endoplasmic reticulum) through ryanodine receptors[@guse2005].
Mechanism of Action	Monoclonal antibody targeting or small molecule inhibitor of NAD+ consuming activity
Primary Expression	various tissues including brain cells (neurons, astrocytes, microglia) and plays important roles in neuro
Druggability	Medium (0.61)
Clinical Stage	Approved
Amino Acids	301 aa
Pathways	Cerebrovascular, Circadian Rhythm, Differentiation, Immune Response, Mitochondrial Function
UniProt ID	H0Y950
Ensembl ID	ENSG00000104419
GeneCards	CD38
Human Protein Atlas	CD38
Associated Diseases	aging, Als, Alzheimer
Known Drugs/Compounds	nicotinamide, NICOTINAMIDE
Interactions	Actin, AGING, AND, APOE, APOPTOSIS, App
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	CD38 Inhibition for NAD+ Restoration and Microglia
KG Connections	612 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — CD38 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1YH3 — X-ray / Cryo-EM

🔮 AI Predicted Structure

H0Y950 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD38["CD38"] -->|"associated"| neurodegeneration["neurodegeneration"]
    CD38["CD38"] -->|"interacts"| NAMPT["NAMPT"]
    CD38["CD38"] -->|"co discussed"| C1Q["C1Q"]
    CD38["CD38"] -->|"co discussed"| NAMPT_1["NAMPT"]
    CD38["CD38"] -->|"co discussed"| GPX4["GPX4"]
    CD38["CD38"] -->|"co discussed"| PLA2G6["PLA2G6"]
    NAMPT_2["NAMPT"] -->|"interacts"| CD38["CD38"]
    MMP9["MMP9"] -->|"co discussed"| CD38["CD38"]
    SLC7A11["SLC7A11"] -->|"co discussed"| CD38["CD38"]
    AQP4["AQP4"] -->|"co discussed"| CD38["CD38"]
    style CD38 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (460)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CD38	data_in	dataset_row	0.00
Lysosomal Cholesterol Efflux	associated_with	process	0.95
Microglial Cells	expressed_in	cell_type	0.90
Neurons	expressed_in	cell_type	0.90
Astrocytes	expressed_in	cell_type	0.90
Neuroinflammation	involved_in	process	0.85
Neurodegeneration	associated_with	process	0.85
Immune Response	associated_with	process	0.85
purinergic signaling	regulates	pathway	0.85
mitochondrial transfer	associated_with	process	0.85
Nad	catalyzes	compound	0.85
nad	regulates	protein	0.85
Mitochondrial Transfer	mediates	mechanism	0.85
Nad	regulates	compound	0.85
mitochondrial transfer	mediates	process	0.85
ADENOSINERGIC PATHWAY	involved_in	entity	0.85
ubiquitin-proteasome	participates_in	pathway	0.80
APOPTOSIS	suppresses	process	0.80
NAD metabolism	involved_in	pathway	0.80
NAMPT	associated_with	gene	0.80
neurodegeneration	contributes_to	phenotype	0.80
programmed cell death	inhibits	process	0.80
NAD+ metabolism	regulates	pathway	0.80
Inflammation	activates	disease	0.75
MIRO1	interacts_with	gene	0.75
Aging	inhibits	disease	0.75
Cancer	associated_with	disease	0.75
Inflammation	associated_with	disease	0.75
ATP production	regulates	process	0.75
astrocytes	expressed_in	cell_type	0.72
microglia	expressed_in	cell_type	0.72
neurons	expressed_in	cell_type	0.72
STING	mediates	gene	0.70
TNF	activates	gene	0.70
MACROPHAGE	regulates	cell_type	0.70
NEURONS	expressed_in	cell_type	0.70
CX3CR1	associated_with	gene	0.70
FOXP3	regulates	gene	0.70
NOTCH	activates	gene	0.70
MICROGLIA	expresses	cell_type	0.70
MACROPHAGE	markers	cell_type	0.70
MACROPHAGE	associated_with	cell_type	0.70
Immune Response	regulates	pathway	0.70
Parkinson's disease	protects_against	disease	0.70
NAD	associated_with	gene	0.70
macrophages	activates	cell_type	0.70
unfolded protein response	participates_in	pathway	0.70
neural stem cells	expressed_in	cell_type	0.70
stem cells	expressed_in	cell_type	0.70
SIRT1	activates	gene	0.70

Incoming (161)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CD38	data_in	dataset_row	0.00
h-cb833ed8	targets	hypothesis	0.90
GJ-PD	upregulates	drug	0.90
GJ-PD herbal pair	upregulates	drug	0.80
SDA-2026-04-01-gap-013	targets	analysis	0.80
Geum japonicum Thunb. var. chinense-Potentilla decorata H. Andres	upregulates	drug	0.80
Aging	upregulates	process	0.80
APOE	causes	gene	0.70
CCL2	associated_with	gene	0.70
ASTROCYTE	expressed_in	cell_type	0.70
ASTROCYTE	protects_against	cell_type	0.70
CANCER	associated_with	gene	0.70
INFLAMMATION	activates	gene	0.70
NAD	activates	gene	0.70
NAD	inhibits	gene	0.70
NAMPT	interacts_with	gene	0.64
aging	activates	phenotype	0.64
NADH	associated_with	gene	0.60
ADORA2B	associated_with	gene	0.60
P2RY12	associated_with	gene	0.60
P2RX1	associated_with	gene	0.60
P2RX4	associated_with	gene	0.60
P2RX7	associated_with	gene	0.60
CCR1	regulates	gene	0.60
MRC1	regulates	gene	0.60
C1QB	regulates	gene	0.60
KIF5B	regulates	gene	0.60
MICRORNAS	associated_with	gene	0.60
MITOCHONDRIA	implicated_in	gene	0.60
GENES	expressed_in	gene	0.60
CYTOKINES	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
DEPRESSION	activates	gene	0.60
BCL-2	treats	gene	0.60
IL-6	activates	gene	0.60
LDL	activates	gene	0.60
ATP	expressed_in	gene	0.60
ATP	treats	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
PYROPTOSIS	treats	gene	0.60
CYTOKINES	treats	gene	0.60
NF-ΚB	inhibits	gene	0.60
IL-6	treats	gene	0.60
INFLAMMATION	treats	gene	0.60
SRC	expressed_in	gene	0.60
CD36	activates	gene	0.60
GENES	associated_with	gene	0.60
ATP	associated_with	gene	0.60
APOPTOSIS	treats	gene	0.60
CXCL12	expressed_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CD38 Inhibition for NAD+ Restoration and Microglial Senescen	0.575	neurodegeneration	Microglial subtypes in neurodegeneration

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning CD38 in their description or question text

No additional research found

CD38

Understanding Entity Pages

Summary

Wiki Pages (3)

CD38 Molecule (CD38)

CD38 Inhibition + NAD+ Precursor Synergy for Neuroprotection

CD38 Inhibitor Therapy for Neurodegeneration

Pathway Diagram

Outgoing (460)

Incoming (161)

Targeting Hypotheses (1)

Mentioning Analyses (4)

Microglial subtypes in neurodegeneration — friend vs foe

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

Mitochondrial transfer between astrocytes and neurons

Senolytic therapy for age-related neurodegeneration

Experiments (0)

Related Papers (0)

Debates (4)

Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma

While APOE4 disrupts microglial metabolism broadly, the debate didn't identify w

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

Mitochondrial transfer between astrocytes and neurons

Related Research