gene

P2RX4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RX4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

0Hypotheses

0Analyses

50Outgoing

37Incoming

0Experiments

0Debates

Summary

P2RX4 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with ALS, Als, Autoimmune. Connected to 65 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	P2RX4
Full Name	Purinergic Receptor P2X 4
Chromosome	12q24.31
Function	The P2RX4 gene encodes the P2X4 receptor subunit, which forms homomeric and heteromeric ion channels permeable to Na⁺, K⁺, and Ca²⁺.
Primary Expression	Brain, Spinal Cord, Microglia, Astrocytes
Pathways	Glucose Homeostasis
UniProt ID	Q99572
NCBI Gene ID	10065
GeneCards	P2RX4
Human Protein Atlas	P2RX4
Associated Diseases	Als, DIABETES, glycemic traits, Inflammation, Ms
Interactions	adora2b, ADORA2B, AND, F3, GENES, P2RX1
KG Connections	101 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: P2RX4 — AlphaFold Q99572 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

P2RX4 Gene

gene · 758 words

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Pathway Diagram

graph TD
    P2RX4["P2RX4"]
    Als{"Als"}
    P2RX4 -->|"associated with"| Als
    Inflammation{"Inflammation"}
    P2RX4 -->|"associated with"| Inflammation
    Ms{"Ms"}
    P2RX4 -->|"associated with"| Ms
    Diabetes{"Diabetes"}
    P2RX4 -->|"protects against"| Diabetes
    Autoimmune{"Autoimmune"}
    P2RX4 -->|"expressed in"| Autoimmune
    Multiple_Sclerosis{"Multiple Sclerosis"}
    P2RX4 -->|"expressed in"| Multiple_Sclerosis
    P2RX4 -->|"expressed in"| Ms
    P2RX4 -->|"expressed in"| Als
    P2RX4 -->|"associated with"| Multiple_Sclerosis
    P2RX4 -->|"regulates"| Ms
    P2RX4 -->|"activates"| Als
    Covid{"Covid"}
    P2RX4 -->|"activates"| Covid
    P2RX1["P2RX1"]
    P2RX1 -->|"therapeutic target"| P2RX4
    ADORA2B["ADORA2B"]
    ADORA2B -->|"activates"| P2RX4
    P2RY12["P2RY12"]
    P2RY12 -->|"activates"| P2RX4
    P2RX1 -->|"activates"| P2RX4
    P2RY1["P2RY1"]
    P2RY1 -->|"protects against"| P2RX4
    P2X7["P2X7"]
    P2X7 -->|"associated with"| P2RX4
    P2RX7["P2RX7"]
    P2RX7 -->|"protects against"| P2RX4
    GAIN["GAIN"]
    GAIN -->|"expressed in"| P2RX4
    CAMKK2["CAMKK2"]
    CAMKK2 -->|"expressed in"| P2RX4
    P2RX7 -->|"expressed in"| P2RX4
    P2X7 -->|"activates"| P2RX4
    P2RX7 -->|"regulates"| P2RX4
    style P2RX4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (64)

Target	Relation	Type	Str
UPREGULATES	upregulates	entity	0.95
LUNG TISSUE	expressed_in	entity	0.95
THERAPEUTIC_TARGET	therapeutic_target	entity	0.90
IMMUNE CELLS	expressed_in	entity	0.90
GLUCOSE HOMEOSTASIS	regulates	entity	0.85
COVID-19	upregulated_in	disease	0.80
Glucose Homeostasis	regulates	process	0.70
glycemic traits	associated_with	phenotype	0.70
ALS	associated_with	disease	0.65
Als	activates	disease	0.65
Covid	activates	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Diabetes	protects_against	disease	0.65
Autoimmune	expressed_in	disease	0.65
Ms	regulates	disease	0.65
P2RY12	activates	gene	0.60
P2RX7	protects_against	gene	0.60
P2RY1	protects_against	gene	0.60
P2X7	associated_with	gene	0.60
P2RX7	expressed_in	gene	0.60
P2RX1	expressed_in	gene	0.60
ADORA2B	activates	gene	0.60
P2RY1	expressed_in	entity	0.60
P2RY14	expressed_in	entity	0.60
P2RX5	regulates	entity	0.60
P2RY1	regulates	entity	0.60
P2RY12	regulates	entity	0.60
PANX1	regulates	entity	0.60
P2RX7	associated_with	entity	0.60
P2RY1	associated_with	entity	0.60
P2RX7	regulates	entity	0.60
ATP	expressed_in	gene	0.60
ATP	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
NAD	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
AND	expressed_in	gene	0.60
AND	activates	gene	0.60
AND	protects_against	gene	0.60
App	therapeutic_target	protein	0.60
App	associated_with	protein	0.60
P2RX7	therapeutic_target	gene	0.60
P2RY14	therapeutic_target	gene	0.60
P2RY1	therapeutic_target	gene	0.60

Incoming (37)

Source	Relation	Type	Str
ATP	therapeutic_target	gene	0.60
P2RX1	therapeutic_target	gene	0.60
ADORA2B	activates	gene	0.60
P2RY12	activates	gene	0.60
P2RX1	activates	gene	0.60
P2RY1	protects_against	gene	0.60
P2X7	associated_with	gene	0.60
P2RX7	protects_against	gene	0.60
GAIN	expressed_in	gene	0.60
CAMKK2	expressed_in	gene	0.60
P2RX7	expressed_in	gene	0.60
P2X7	activates	gene	0.60
P2RX7	regulates	gene	0.60
P2RY1	therapeutic_target	gene	0.60
P2RY1	activates	gene	0.60
P2RX7	activates	gene	0.60
CD38	associated_with	gene	0.60
P2RY14	expressed_in	gene	0.60
P2RY1	expressed_in	gene	0.60
P2RX1	expressed_in	gene	0.60
P2RX5	activates	gene	0.60
PANX1	activates	gene	0.60
ADORA2B	regulates	entity	0.60
P2RX1	regulates	entity	0.60
P2RX7	therapeutic_target	gene	0.60
P2RY14	therapeutic_target	gene	0.60
GENES	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
F3	activates	gene	0.60
GENES	associated_with	gene	0.60
ATP	associated_with	gene	0.60
ATP	expressed_in	gene	0.60
NAD	associated_with	gene	0.60
CD38	co_expressed_with	gene	0.50
P2RX1	co_expressed_with	gene	0.50
adora2b	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning P2RX4 in their description or question text

No additional research found