| Gene Symbol | VPS13CV2 |
| Aliases | VPS13CV2 |
| Chromosome | 15q22.31 |
| Brain | Particularly in substantia nigra dopaminergic neurons |
| Pancreas | Beta cells and exocrine tissue |
| Testis | High expression levels |
| ER-mitochondria contacts | Transfers phospholipids for mitochondrial membrane maintenance |
| ER-lipid droplet contacts | Regulates lipid storage and mobilization |
| ER-endolysosomal contacts | Supports endolysosomal membrane homeostasis |
| Recruitment to damaged mitochondria | Responds to loss of mitochondrial membrane potential |
| Interaction with PINK1/Parkin | Works in concert with the canonical mitophagy pathway |
| Lysosomal membrane integrity | Ensures proper lysosomal function |
| Endosome maturation | Supports trafficking through the endolysosomal system |
| Lysosomal pH regulation | Contributes to acidification and enzyme activity |
| Age at onset | 20-40 years (early-onset) |
| Motor symptoms | Tremor, bradykinesia, rigidity |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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