gene

TUBB2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUBB2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

4Outgoing

4Incoming

0Experiments

0Debates

Summary

TUBB2A encodes neuron-specific beta-2-tubulin, critical for microtubule formation in axons and dendrites. Mutations cause cortical malformations and it's implicated in Alzheimer's and Parkinson's diseases.

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🧬 Gene Info

Gene Symbol	TUBB2A
Full Name	Tubulin Beta 2A Class IIa
Chromosome	12p12.3
Protein Family	Tubulin beta family
Function	is a critical neuronal gene located on chromosome 12p12.
Primary Expression	Brain (high), testis
Molecular Weight	50 kDa
Amino Acids	445 aa
UniProt ID	Q9H4B7
NCBI Gene ID	7280
Ensembl ID	ENSG00000137267
OMIM	615101
GeneCards	TUBB2A
Human Protein Atlas	TUBB2A
Cerebral cortex	particularly layer 5 pyramidal neurons
Associated Diseases	Cancer, Glioblastoma, Ms, Tumor
KG Connections	8 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TUBB2A — AlphaFold Q9H4B7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TUBB2A — Tubulin Beta 2A Class IIa

gene · 2613 words

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TUBB2A Protein

protein · 861 words

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Pathway Diagram

graph TD
    TUBB2A["TUBB2A"]
    Ms{"Ms"}
    TUBB2A -->|"associated with"| Ms
    Cancer{"Cancer"}
    TUBB2A -->|"associated with"| Cancer
    Tumor{"Tumor"}
    TUBB2A -->|"associated with"| Tumor
    Glioblastoma{"Glioblastoma"}
    TUBB2A -->|"associated with"| Glioblastoma
    neurodegeneration["neurodegeneration"]
    TUBB2A -->|"implicated in"| neurodegeneration
    SSBP1["SSBP1"]
    SSBP1 -->|"biomarker for"| TUBB2A
    RPA3["RPA3"]
    RPA3 -->|"biomarker for"| TUBB2A
    CANCER["CANCER"]
    CANCER -->|"associated with"| TUBB2A
    GBM["GBM"]
    GBM -->|"expressed in"| TUBB2A
    style TUBB2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65

Incoming (4)

Source	Relation	Type	Str
SSBP1	biomarker_for	gene	0.60
RPA3	biomarker_for	gene	0.60
GBM	expressed_in	gene	0.60
CANCER	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TUBB2A in their description or question text

No additional research found