gene

PSMB7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSMB7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

16Outgoing

2Incoming

0Experiments

0Debates

Summary

Page for PSMB7

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🧬 Gene Info

Gene Symbol	PSMB7
Chromosome	9q34.3
Protein Type	Protease, Hydrolase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Ubiquitous (all tissues)
Molecular Weight	30.2 kDa
UniProt ID	P99416
NCBI Gene ID	5719
Ensembl ID	ENSG00000136930
OMIM	176843
GeneCards	PSMB7
Human Protein Atlas	PSMB7
Interactions	APP, PSMA5, SLC1A2
KG Connections	18 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PSMB7 — AlphaFold P99416 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PSMB7

gene · 1117 words

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PSMB7 Protein

protein · 678 words

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Pathway Diagram

graph TD
    PSMB7["PSMB7"]
    Alzheimer{"Alzheimer"}
    PSMB7 -->|"expressed in"| Alzheimer
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    PSMB7 -->|"expressed in"| ALZHEIMER_S_DISEASE
    P53["P53"]
    PSMB7 -->|"expressed in"| P53
    APP["APP"]
    PSMB7 -->|"inhibits"| APP
    PSMA5["PSMA5"]
    PSMB7 -->|"inhibits"| PSMA5
    Neurogenesis(["Neurogenesis"])
    PSMB7 -->|"expressed in"| Neurogenesis
    neurodegeneration["neurodegeneration"]
    PSMB7 -->|"implicated in"| neurodegeneration
    style PSMB7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

Target	Relation	Type	Str
Neurodegeneration	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Tauopathy	interacts_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
APP	inhibits	gene	0.60
PSMA5	inhibits	gene	0.60
SLC1A2	interacts_with	gene	0.60
PSP	associated_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
P53	expressed_in	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Neurogenesis	expressed_in	pathway	0.60
Proteasome	associated_with	pathway	0.60
Neurogenesis	interacts_with	pathway	0.60

Incoming (2)

Source	Relation	Type	Str
APP	downregulates	protein	0.70
TAU	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PSMB7 in their description or question text

No additional research found