protein

FMRP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FMRP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

1Hypotheses

2Analyses

46Outgoing

11Incoming

0Experiments

3Debates

Summary

Page for FMRP Protein

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🔬 Protein Info

Gene Symbol	FMRP
Function	Fmrp Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Pathways	Chromatin Dynamics, RNA Binding, mRNA Translation, mRNA Transport
GeneCards	FMRP
Human Protein Atlas	FMRP
Associated Diseases	ALS, fragile X syndrome
Interactions	CDK5, DNA, FMR1, HNRNPA2B1, RNA, SYNCRIP
KG Connections	49 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FMRP Protein

protein · 629 words

→

CYFIP2 — Cytoplasmic FMRP Interacting Protein 2

gene · 779 words

→

Pathway Diagram

graph TD
    FMRP["FMRP"]
    Chromatin_Dynamics["Chromatin Dynamics"]
    FMRP -->|"participates_in"| Chromatin_Dynamics
    RNA_Binding["RNA Binding"]
    FMRP -->|"participates_in"| RNA_Binding
    mRNA_Transport["mRNA Transport"]
    FMRP -->|"participates_in"| mRNA_Transport
    mRNA_Translation["mRNA Translation"]
    FMRP -->|"participates_in"| mRNA_Translation
    SLC1A2(["SLC1A2"])
    FMRP -->|"regulates"| SLC1A2
    Tdp_43["Tdp-43"]
    FMRP -->|"associated_with"| Tdp_43
    AUTISM{"AUTISM"}
    AUTISM -->|"activates"| FMRP
    FMR1(["FMR1"])
    FMR1 -->|"activates"| FMRP
    style FMRP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (46)

Target	Relation	Type	Str
h-811f3e6d09	targeted_by	hypothesis	1.00
h-815e1cb9c9	targeted_by	hypothesis	1.00
RNA Metabolism	regulates	process	0.90
fragile X syndrome	associated_with	disease	0.90
GBA mRNA translation	regulates	process	0.90
mRNA Transport	participates_in	process	0.80
TDP-43	mitigates_toxicity	protein	0.80
RNA Binding	participates_in	process	0.80
mRNA Translation	participates_in	process	0.80
Chromatin Dynamics	participates_in	process	0.80
neurons	expressed_in	cell_type	0.80
neuronal granules	regulates	process	0.70
GBA mRNA	regulates	molecule	0.70
RNA	interacts_with	gene	0.65
SLC1A2	regulates	gene	0.60
RNA	regulates	gene	0.60
autism spectrum disorder	regulates	disease	0.60
RNA	activates	gene	0.60
G3BP1	associated_with	gene	0.60
G3BP2	associated_with	gene	0.60
autism spectrum disorder	activates	disease	0.60
astrocytes	expressed_in	cell_type	0.60
ALS	associated_with	disease	0.60
TDP-43	interacts_with	gene	0.55
HNRNPA2B1	interacts_with	gene	0.55
SYNCRIP	interacts_with	gene	0.55
TAR	interacts_with	gene	0.55
Neuron	activates	cell_type	0.50
GLUTAMATE	regulates	concept	0.50
Astrocytes	activates	cell_type	0.50
GLUTAMATE	inhibits	concept	0.50
Astrocyte	inhibits	cell_type	0.50
Astrocytes	inhibits	cell_type	0.50
Astrocyte	activates	cell_type	0.50
Tdp-43	inhibits	pathway	0.50
Tdp-43	interacts_with	pathway	0.50
Tdp-43	activates	pathway	0.50
MOTOR NEURONS	activates	concept	0.50
Tdp-43	associated_with	pathway	0.50
STRESS GRANULES	activates	concept	0.50
SYNAPSE	inhibits	concept	0.50
MOTOR NEURONS	inhibits	concept	0.50
NEURONS	inhibits	concept	0.50
NEURONS	activates	concept	0.50
G3BP1	co_expressed_with	gene	0.50
G3BP2	co_expressed_with	gene	0.50

Incoming (11)

Source	Relation	Type	Str
h-811f3e6d09	targets	hypothesis	1.00
h-815e1cb9c9	targets	hypothesis	1.00
34290090	sequester and promote phase separation of	paper	0.90
24346713	interacts with	paper	0.90
24346713	represses	paper	0.90
11438589	may play a role in	paper	0.60
CDK5	inhibits	gene	0.60
DNA	interacts_with	gene	0.55
AUTISM	activates	disease	0.50
FMR1	activates	gene	0.50
FMR1	inhibits	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Competition with G3BP1-Caprin1/FMRP Scaffold Formation	0.590	neurodegeneration	How does TRIM21-mediated K63 ubiquitinat

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.645

What determines the specificity of RNA-protein interactions that drive distinct

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.712

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Debate: Liquid-to-Solid Transition Pathology Reveals Granule Weak Points

closed · Rounds: 4 · Score: 0.58 · 2026-04-27

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

While the study identifies G3BP1 as a central node triggering phase separation,

closed · Rounds: 4 · Score: 0.76 · 2026-04-21

Related Research

Hypotheses and analyses mentioning FMRP in their description or question text

No additional research found