concept

PCSK9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PCSK9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

245Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PCSK9 is a concept in neurodegeneration research. Key relationships include: inhibits, activates, associated with. Associated with ADH, ALS, ARM. Connected to 128 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	PCSK9
Key Genes/Proteins	ADRA2A, AKT, AMPK, AND, APC, APOB
Related Diseases	ADH, Aging, Als, ALS, Alzheimer's disease
Related Pathways	Akt

Pathway Diagram

graph TD
    PCSK9["PCSK9"]
    PCSK9 -->|"inhibits"| LDLR["LDLR"]
    PCSK9 -->|"activates"| platelet_activation["platelet activation"]
    PCSK9 -->|"activates"| leukocyte_recruitment["leukocyte recruitment"]
    PCSK9 -->|"activates"| clot_formation["clot formation"]
    PCSK9 -->|"regulates"| LDL_C["LDL-C"]
    PCSK9 -->|"causes"| ADH["ADH"]
    PCSK9 -->|"regulates"| serum_cholesterol_levels["serum cholesterol levels"]
    PCSK9 -->|"inhibits"| Cardiovascular["Cardiovascular"]
    PCSK9 -->|"target for"| Atherosclerosis["Atherosclerosis"]
    PCSK9 -->|"activates"| Als["Als"]
    inclisiran["inclisiran"] -->|"inhibits"| PCSK9
    evolocumab["evolocumab"] -->|"inhibits"| PCSK9
    alirocumab["alirocumab"] -->|"inhibits"| PCSK9
    base_editing["base editing"] -->|"regulates"| PCSK9
    LDLR -->|"activates"| PCSK9
    APOB["APOB"] -->|"expressed in"| PCSK9
    GENES["GENES"] -->|"expressed in"| PCSK9
    SOD1["SOD1"] -->|"inhibits"| PCSK9
    HMGB2["HMGB2"] -->|"inhibits"| PCSK9

Outgoing (147)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PCSK9	data_in	dataset_row	0.00
LDLR	inhibits	protein	0.95
Atherosclerotic Plaque Development	contributes_to	process	0.90
LDL-C Levels	upregulates	biomarker	0.90
Platelet Activation	associated_with	process	0.85
Autosomal Dominant Hypercholesterolemia	risk_factor_for	disease	0.85
Leukocyte Recruitment	associated_with	process	0.85
leukocyte recruitment	activates	phenotype	0.75
Aging	therapeutic_target	disease	0.75
clot formation	activates	phenotype	0.75
Als	associated_with	disease	0.75
platelet activation	activates	phenotype	0.75
LDL-C	regulates	protein	0.72
ADH	causes	disease	0.72
LDL	inhibits	gene	0.70
serum cholesterol levels	regulates	process	0.70
MACROPHAGES	activates	cell_type	0.70
lipid metabolism	participates_in	pathway	0.70
Tumor	activates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Hypertension	expressed_in	disease	0.65
Anorectal Malformation	biomarker_for	disease	0.65
Stroke	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cardiovascular	associated_with	disease	0.65
Atherosclerosis	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Ms	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Neuroinflammation	inhibits	disease	0.65
LDLR	associated_with	gene	0.65
ALS	activates	disease	0.65
Cardiovascular	inhibits	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Cardiac	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Aging	activates	disease	0.65
ALS	expressed_in	disease	0.65
Inflammation	inhibits	disease	0.65
Cardiovascular	regulates	disease	0.65
Type 2 Diabetes	associated_with	disease	0.65

Incoming (98)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PCSK9	data_in	dataset_row	0.00
inclisiran	inhibits	drug	0.95
alirocumab	inhibits	drug	0.72
evolocumab	inhibits	drug	0.72
base editing	regulates	process	0.70
LDL	regulates	gene	0.70
GLUTAMATE	targets	phenotype	0.65
COMPLEMENT	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
AND	associated_with	gene	0.60
MYELIN	activates	gene	0.60
STROKE	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
SYN1	activates	gene	0.60
MBP	activates	gene	0.60
RAC1	activates	gene	0.60
NEURON	activates	gene	0.60
MOG	activates	gene	0.60
AXON	activates	gene	0.60
GFAP	activates	gene	0.60
AND	activates	gene	0.60
VESICLE TRAFFICKING	activates	gene	0.60
LDL	inhibits	gene	0.60
APOB	associated_with	gene	0.60
RNA	inhibits	gene	0.60
AND	inhibits	gene	0.60
AND	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
SIRT1	therapeutic_target	gene	0.60
AMPK	therapeutic_target	gene	0.60
AKT	expressed_in	gene	0.60
APOE	activates	gene	0.60
AKT	activates	gene	0.60
ERK	activates	gene	0.60
EGF	associated_with	gene	0.60
LDLR	interacts_with	gene	0.60
EGF	inhibits	gene	0.60
STROKE	inhibits	gene	0.60
C1QA	activates	gene	0.60
LDL	activates	gene	0.60
LDL	targets	gene	0.60
APC	activates	gene	0.60
KRAS	activates	gene	0.60
MEK	activates	gene	0.60
APC	inhibits	gene	0.60
KRAS	inhibits	gene	0.60
APC	biomarker_for	gene	0.60
KRAS	biomarker_for	gene	0.60
ADRA2A	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PCSK9 in their description or question text

No additional research found