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gene 782 words KG: PSAP
Contents

PSAP Gene - Prosaposin

🧬 Gene Info
Gene SymbolPSAP
AliasesPage for PSAP Gene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionsubstantia nigra, Substantia Nigra
Molecular Weight58.4 kDa
Amino Acids557 aa
PathwaysOxidative Phosphorylation, Sphingolipid
GeneCardsPSAP
Human Protein AtlasPSAP
Associated Diseasesneuroinflammation
InteractionsAND, APOE, AUTOPHAGY, CANCER, CTSD, GALC
KG Connections171 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (17)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78CYP46A1 Overexpression Gene Therapy
Score: 0.77APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72Membrane Cholesterol Gradient Modulators
Score: 0.71Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69Ganglioside Rebalancing Therapy
Score: 0.69Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68Oligodendrocyte White Matter Vulnerability
Score: 0.65LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (5)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

ARSA Gene
gene · KG edge: contributes_toCTSD — Cathepsin D
gene · KG edge: interacts_withGALC Gene
gene · KG edge: contributes_toGLA Gene - Alpha-Galactosidase A
gene · KG edge: contributes_toGPR37 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

PSAP activates GPR37
PSAP activates IL6
PSAP associated_with MTOR
PSAP therapeutic_target APOE
PSAP inhibits LDLR
GPR37 activates PSAP
MTOR associated_with PSAP
APOE therapeutic_target PSAP
APOE regulates PSAP
LDLR inhibits PSAP

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