| Gene Symbol | PSAP |
| Aliases | Page for PSAP Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | substantia nigra, Substantia Nigra |
| Subcellular Localization | </th><td>Lysosome, Secreted</td></tr> |
| Molecular Weight | 58.4 kDa |
| Amino Acids | 557 aa |
| Pathways | Oxidative Phosphorylation, Sphingolipid |
| GeneCards | PSAP |
| Human Protein Atlas | PSAP |
| Signal peptide | N-terminal targeting sequence |
| Saposins A, B, C, D | Four homologous domains (~80 aa each) |
| Saposin A | Activates glucocerebrosidase (hydrolyzes glucosylceramide) |
| Saposin B | Activates arylsulfatase A (hydrolyzes cerebroside sulfate) |
| Saposin C | Activates β-glucosidase and β-galactocerebrosidase |
| Associated Diseases | Neurodegeneration, neurodegeneration |
| Interactions | AND, APOE, AUTOPHAGY, CANCER, CTSD, GALC |
| KG Connections | 171 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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