| Gene Symbol | PSAP |
| Full Name | GPR37-IL-6 Axis in Parkinson's Disease |
| Aliases | Page for PSAP Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | substantia nigra, Substantia Nigra |
| Molecular Weight | 58.4 kDa |
| Amino Acids | 557 aa |
| Pathways | Oxidative Phosphorylation, Sphingolipid |
| GeneCards | PSAP |
| Human Protein Atlas | PSAP |
| Oligodendrocyte expression | Originally characterized in neurons, GPR37 is also expressed in oligodendrocytes |
| PSAP as ligand | PSAP acts as a ligand for GPR37, triggering downstream signaling |
| Upregulation in PD | GPR37 expression increases in oligodendrocytes in the parkinsonian brain |
| Pathogenic signaling | GPR37 activation triggers pro-inflammatory signaling cascades |
| GPR37 knockout mice | Resistant to dopamine neuron loss in genetic PD models |
| Associated Diseases | Neurodegeneration, neurodegeneration |
| Interactions | AND, APOE, AUTOPHAGY, CANCER, CTSD, GALC |
| KG Connections | 170 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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