| Gene Symbol | NEFM |
| Full Name | Neurofilament Medium Chain |
| Chromosome | 8q21.3 |
| Function | The NEFM gene encodes the 102.5 kDa neurofilament medium polypeptide, which assembles with neurofilament light chain (NEFL) and heavy chain (NEFH) to form the neuronal intermediate filament cytoskelet |
| Primary Expression | Motor neurons, Sensory neurons, Spinal cord, Brainstem, Hippocampus, Cerebral cortex |
| Subcellular Localization | </th><td>Cytoplasm, Neuronal axons</td></tr> |
| Molecular Weight | 102.5 kDa |
| UniProt ID | P12036 |
| NCBI Gene ID | 4741 |
| Ensembl ID | ENSG00000104722 |
| OMIM | 162400 |
| GeneCards | NEFM |
| Human Protein Atlas | NEFM |
| CSF NEFM | FDA-approved biomarker for traumatic brain injury |
| Blood NEFM | Emerging biomarker for AD, PD, and ALS progression |
| Interactions | AIF1, AMPK, ARC, CAMKK2, CNR1, COX4I1 |
| KG Connections | 51 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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