concept

TAU PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAU PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

301Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TAU PROTEIN
Key Genes/Proteins	NFKB, VPS35
Related Diseases	Alzheimer's Disease, Tauopathies

Pathway Diagram

graph TD
    TAU_PROTEIN["TAU PROTEIN"]
    style TAU_PROTEIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    TAU_PROTEIN -.->|"biomarker for"| Alzheimer_s_Disease["Alzheimer's Disease"]
    TAU_PROTEIN -.->|"biomarker for"| Tauopathies["Tauopathies"]
    TAU_PROTEIN -->|"involved_in"| Hyperphosphorylation["Hyperphosphorylation"]
    TAU_PROTEIN -->|"expressed in"| Retina["/Retina/"]
    TAU_PROTEIN -->|"causes"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    TAU_PROTEIN -->|"interacts"| NFKB([NFKB])
    TAU_PROTEIN -->|"causes"| neuronal_damage["neuronal damage"]
    TAU_PROTEIN -->|"activates"| Reactive_oxygen_species["Reactive oxygen species"]
    Alzheimer_s_Disease -.->|"biomarker for"| TAU_PROTEIN
    Cerebrospinal_Fluid["Cerebrospinal Fluid"] -->|"component_of"| TAU_PROTEIN
    Post_translational_Modificatio["Post-translational Modifications"] -->|"regulates"| TAU_PROTEIN
    MAPT([MAPT]) -->|"encodes"| TAU_PROTEIN
    NBR1([NBR1]) -->|"interacts"| TAU_PROTEIN
    CBD{"CBD"} -->|"regulates"| TAU_PROTEIN
    Cannabidiol{"Cannabidiol"} -.->|"inhibits"| TAU_PROTEIN
    FBXW7([FBXW7]) -->|"regulates"| TAU_PROTEIN

Outgoing (125)

Target	Relation	Type	Str
Tauopathies	involved_in	disease	0.95
Neurofibrillary Tangles	causes	entity	0.95
Alzheimer's Disease	biomarker_for	disease	0.95
Hyperphosphorylation	involved_in	process	0.95
Tauopathies	biomarker_for	disease	0.95
Alzheimer'S Disease	contributes_to	disease	0.95
Alzheimer's Disease	associated_with	disease	0.95
Axonal Structure	regulates	structure	0.92
Axonal Transport	regulates	process	0.92
Retina	expressed_in	cell_type	0.90
cytoskeletal remodeling	associated_with	process	0.90
Alzheimer'S Disease	causes	disease	0.90
tau protein hyperphosphorylation	involved_in	process	0.90
CSF tau assays	biomarker_for	process	0.88
Alzheimer's Disease	causes	disease	0.80
NFKB	interacts_with	protein	0.80
RNA-binding proteins	interacts_with	protein	0.70
Oxidative Stress	interacts_with	process	0.70
Alzheimer's disease	associated_with	disease	0.70
fibrillar structures	promotes	process	0.70
Reactive oxygen species	activates	process	0.70
neurofibrillary tangles	promotes	process	0.70
RNA	interacts_with	process	0.70
cognitive dysfunction	associated_with	process	0.70
Alzheimer's disease	causes	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
neurodegenerative diseases	associated_with	disease	0.70
trans-synaptic propagation	associated_with	process	0.70
neuronal damage	causes	process	0.70
Parkinson's Disease	implicated_in	disease	0.65
Aging	therapeutic_target	disease	0.60
Alzheimer	activates	disease	0.60
Als	activates	disease	0.60
Als	biomarker_for	disease	0.60
Neurodegeneration	activates	disease	0.60
Als	stabilizes	disease	0.60
Dementia	biomarker_for	disease	0.60
Dementia	stabilizes	disease	0.60
Alzheimer	protects_against	disease	0.60
Tauopathy	stabilizes	disease	0.60
Parkinson	associated_with	disease	0.60
Alzheimer	biomarker_for	disease	0.60
Neurodegeneration	causes	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Neuroinflammation	biomarker_for	disease	0.60
Frontotemporal Dementia	stabilizes	disease	0.60
Alzheimer	causes	disease	0.60
Aging	biomarker_for	disease	0.60
Neurodegeneration	biomarker_for	disease	0.60
Huntington	therapeutic_target	disease	0.60

Incoming (176)

Source	Relation	Type	Str
MAPT	associated_with	gene	0.95
MAPT	associated_with	gene	0.95
41090735	plays pivotal roles in	paper	0.90
Hyperphosphorylation	modulates	process	0.90
VPS35	regulates	protein	0.85
MTOR	enhances	gene	0.80
MTOR	regulates	gene	0.80
Post-translational Modifications	regulates	process	0.80
Alzheimer's disease	associated_with	disease	0.70
MAPT	encodes	gene	0.70
CBD	regulates	drug	0.70
Cannabidiol	inhibits	drug	0.70
NBR1	regulates	protein	0.70
MTOR	activates	gene	0.70
LRP1	regulates	gene	0.70
MAPT	encodes	gene	0.70
NBR1	interacts_with	protein	0.70
MITOCHONDRIA	associated_with	gene	0.60
PINK1	phosphorylates	gene	0.60
OVERVIEW	associated_with	gene	0.60
AQUAPORIN-4	associated_with	gene	0.60
AQP4	associated_with	gene	0.60
TAU	causes	gene	0.60
AGING	causes	gene	0.60
APOE	interacts_with	gene	0.60
APP/PS1	activates	gene	0.60
AMYLOID	expressed_in	gene	0.60
MICROGLIA	regulates	gene	0.60
PHAGOCYTOSIS	regulates	gene	0.60
BDNF	activates	gene	0.60
APP	biomarker_for	gene	0.60
TAU	phosphorylates	gene	0.60
AMYLOID-BETA	phosphorylates	gene	0.60
TNF	activates	gene	0.60
PARKIN	phosphorylates	gene	0.60
MICROGLIA	associated_with	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
ASTROCYTES	associated_with	gene	0.60
NF-KB	therapeutic_target	gene	0.60
MICROTUBULES	interacts_with	gene	0.60
DEMENTIA	stabilizes	gene	0.60
DEMENTIA	biomarker_for	gene	0.60
DEMENTIA	causes	gene	0.60
ALZHEIMER	causes	gene	0.60
APOE	associated_with	gene	0.60
AGING	associated_with	gene	0.60
BACE1	therapeutic_target	gene	0.60
SREBP2	therapeutic_target	gene	0.60
ABCA1	therapeutic_target	gene	0.60
CYP46A1	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Pericyte senescence is sufficient to weaken the BBB even wit	0.630	neurodegeneration	Does pericyte senescence drive BBB break

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TAU PROTEIN in their description or question text

No additional research found