Contents

MS4A4A/MS4A6A → TREM2 Negative Regulation → Microglial Dysfunction → AD Causal Chain

🔬 Protein Info

Gene Symbol	ent-gene-c9882297
Chromosome	11q12
Modulate CSF sTREM2 levels	Certain MS4A4A variants are associated with reduced soluble TREM2 in cerebrospinal fluid[@demon2022]
Affect microglial activation states	Expression quantitative trait loci (eQTLs) influence microglial transcriptional programs
Modify disease progression	Some variants correlate with faster cognitive decline
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

No AI portrait yet

Knowledge Graph