gene

MS4A4E

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MS4A4E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

23Outgoing

18Incoming

0Experiments

0Debates

Summary

Page for MS4A4E Gene - Membrane-Spanning 4-Domains A4E

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🧬 Gene Info

Gene Symbol	MS4A4E
Full Name	Membrane-Spanning 4-Domains A4E
Aliases	Page for MS4A4E Gene
Chromosome	11q12.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Brain, Spleen, Lymphocytes, Monocytes
UniProt ID	Q9NRL3
NCBI Gene ID	245722
Ensembl ID	ENSG00000166908
GeneCards	MS4A4E
Human Protein Atlas	MS4A4E
MS4A3	Myeloid/lymphoid differentiation
MS4A4A/MS4A4E	Brain and immune function
Associated Diseases	Alzheimer
Interactions	ABCA7, AND, APOE, BIN1, CD2AP, CLU
KG Connections	41 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MS4A4E — AlphaFold Q9NRL3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MS4A4E Gene - Membrane-Spanning 4-Domains A4E

gene · 661 words

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Pathway Diagram

graph TD
    MS4A4E["MS4A4E"]
    Alzheimer["Alzheimer"]
    MS4A4E -->|"associated with"| Alzheimer
    CLU["CLU"]
    MS4A4E -->|"interacts with"| CLU
    APOE["APOE"]
    MS4A4E -->|"interacts with"| APOE
    BIN1["BIN1"]
    MS4A4E -->|"interacts with"| BIN1
    CD2AP["CD2AP"]
    MS4A4E -->|"interacts with"| CD2AP
    TOMM40["TOMM40"]
    MS4A4E -->|"interacts with"| TOMM40
    NME8["NME8"]
    MS4A4E -->|"interacts with"| NME8
    MIRNAS["MIRNAS"]
    MS4A4E -->|"associated with"| MIRNAS
    PTK2B["PTK2B"]
    MS4A4E -->|"interacts with"| PTK2B
    AND["AND"]
    MS4A4E -->|"interacts with"| AND
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    MS4A4E -->|"associated with"| ALZHEIMER_S_DISEASE
    GENES["GENES"]
    MS4A4E -->|"interacts with"| GENES
    ALZHEIMER["ALZHEIMER"]
    MS4A4E -->|"associated with"| ALZHEIMER
    MS4A6A["MS4A6A"]
    MS4A4E -->|"interacts with"| MS4A6A
    PICALM["PICALM"]
    MS4A4E -->|"interacts with"| PICALM
    Amyloid["Amyloid"]
    MS4A4E -->|"associated with"| Amyloid
    ZCWPW1["ZCWPW1"]
    ZCWPW1 -->|"interacts with"| MS4A4E
    GAB2["GAB2"]
    GAB2 -->|"interacts with"| MS4A4E
    CR1["CR1"]
    CR1 -->|"interacts with"| MS4A4E
    MS4A6A["MS4A6A"]
    MS4A6A -->|"interacts with"| MS4A4E
    ABCA7["ABCA7"]
    ABCA7 -->|"interacts with"| MS4A4E
    PICALM["PICALM"]
    PICALM -->|"interacts with"| MS4A4E
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| MS4A4E
    PTK2B["PTK2B"]
    PTK2B -->|"interacts with"| MS4A4E
    CD2AP["CD2AP"]
    CD2AP -->|"interacts with"| MS4A4E
    APOE["APOE"]
    APOE -->|"interacts with"| MS4A4E
    BIN1["BIN1"]
    BIN1 -->|"interacts with"| MS4A4E
    NME8["NME8"]
    NME8 -->|"interacts with"| MS4A4E
    AMYLOID["AMYLOID"]
    AMYLOID -->|"associated with"| MS4A4E
    neurodegeneration["neurodegeneration"]
    MS4A4E -->|"implicated in"| neurodegeneration

Outgoing (23)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
MIRNAS	associated_with	gene	0.60
AND	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
Amyloid	associated_with	pathway	0.60
App	associated_with	protein	0.60
MS4A6A	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
TOMM40	interacts_with	gene	0.60
NME8	interacts_with	gene	0.60
PTK2B	interacts_with	gene	0.60
GAB2	interacts_with	gene	0.60
ABCA7	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
ZCWPW1	interacts_with	gene	0.50
PICALM	co_mentioned	gene	0.40
ZCWPW1	co_mentioned	gene	0.40

Incoming (18)

Source	Relation	Type	Str
MIRNAS	associated_with	gene	0.60
PTK2B	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
NME8	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
ZCWPW1	interacts_with	gene	0.60
GAB2	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
MS4A6A	interacts_with	gene	0.60
ABCA7	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
APOE	co_mentioned	gene	0.40
CLU	co_mentioned	gene	0.40
GAB2	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MS4A4E in their description or question text

No additional research found