gene

APOC3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APOC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

112Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

A gene referenced in 100 knowledge graph relationships. Key connections: inhibits Atherosclerosis (disease); associated_with Aging (disease); associated_with Als (disease).

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🧬 Gene Info

Gene Symbol	APOC3
Full Name	Apolipoprotein C-III
Aliases	ApoC-III
Chromosome	11q23.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Hepatocytes in the liver (highest expression)
Molecular Weight	8.8 kDa
Amino Acids	79 aa
Pathways	Cholesterol
NCBI Gene ID	345
Ensembl ID	ENSG00000110245
GeneCards	APOC3
Human Protein Atlas	APOC3
Associated Diseases	Aging, Als, Atherosclerosis, Cardiovascular
Interactions	ABCA1, ABCA2, APOA1, APOC1, APOC2, APOD
KG Connections	100 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

APOC3 Gene

gene · 838 words

→

APOC3 Protein

protein · 998 words

→

Pathway Diagram

flowchart TD
    A["APOC3"] --> B["LPL Inhibition"]
    A --> C["Triglyceride-Rich Lipoproteins"]
    C --> D["Atherosclerosis"]
    B --> D
    A --> E["Ferroptosis Regulation"]
    E --> F["Iron Accumulation"]
    E --> G["Lipid Peroxidation"]
    F --> H["Oxidative Cell Death"]
    G --> H
    H --> I["Neurodegeneration"]
    D --> J["Cerebral Vessel Dysfunction"]

Outgoing (55)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:APOC3	data_in	dataset_row	0.00
Atherosclerosis	inhibits	disease	0.80
Als	degrades	disease	0.65
Atherosclerosis	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	transports	disease	0.65
Alzheimer	transports	disease	0.65
ALS	transports	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Als	associated_with	disease	0.65
Atherosclerosis	degrades	disease	0.65
Cholesterol	associated_with	pathway	0.60
Cholesterol	activates	pathway	0.60
Neuron	activates	cell_type	0.60
ALZHEIMER	degrades	gene	0.60
APOD	activates	gene	0.60
TFCP2	degrades	gene	0.60
LIPA	degrades	gene	0.60
CYP46A1	activates	gene	0.60
LDLR	activates	gene	0.60
LRP1	activates	gene	0.60
LRP8	activates	gene	0.60
SOAT1	activates	gene	0.60
DGAT2	associated_with	gene	0.60
PCSK9	associated_with	gene	0.60
CH25H	activates	gene	0.60
lipid metabolism	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
LDLR	associated_with	gene	0.60
APOC2	transports	gene	0.60
APP	degrades	gene	0.60
PSEN2	degrades	gene	0.60
APOA1	activates	gene	0.60
MAPT	degrades	gene	0.60
SREBF1	degrades	gene	0.60
NCSTN	degrades	gene	0.60
PSEN1	degrades	gene	0.60
APOE	activates	gene	0.60
ABCA1	activates	gene	0.60
APOC1	activates	gene	0.60
ABCA2	activates	gene	0.60
GSK3B	degrades	gene	0.60
APOC2	activates	gene	0.60
TAU	degrades	gene	0.60
Neuron	expressed_in	cell_type	0.55
Ca1	expressed_in	brain_region	0.55
LDLR	activates	gene	0.50

Incoming (57)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:APOC3	data_in	dataset_row	0.00
TFCP2	transports	gene	0.60
AND	transports	gene	0.60
ALZHEIMER'S DISEASE	transports	gene	0.60
CH25H	transports	gene	0.60
APOD	transports	gene	0.60
GENES	transports	gene	0.60
ALZHEIMER	transports	gene	0.60
SREBF1	transports	gene	0.60
ABCA2	transports	gene	0.60
PSEN1	transports	gene	0.60
TAU	transports	gene	0.60
APOC1	transports	gene	0.60
LRP1	transports	gene	0.60
CH25H	activates	gene	0.60
APOE	transports	gene	0.60
NCSTN	transports	gene	0.60
PSEN2	transports	gene	0.60
LIPA	transports	gene	0.60
LDLR	transports	gene	0.60
ABCA1	transports	gene	0.60
GSK3B	transports	gene	0.60
LRP8	transports	gene	0.60
APOA1	transports	gene	0.60
CYP46A1	transports	gene	0.60
SOAT1	transports	gene	0.60
APP	transports	gene	0.60
MAPT	transports	gene	0.60
ALZHEIMER	regulates	gene	0.60
APOD	activates	gene	0.60
TFCP2	regulates	gene	0.60
LRP8	activates	gene	0.60
APOA1	activates	gene	0.60
MAPT	regulates	gene	0.60
LRP1	activates	gene	0.60
LIPA	regulates	gene	0.60
APP	regulates	gene	0.60
APOE	activates	gene	0.60
CYP46A1	activates	gene	0.60
ABCA1	activates	gene	0.60
NCSTN	regulates	gene	0.60
GSK3B	regulates	gene	0.60
PSEN1	regulates	gene	0.60
SREBF1	regulates	gene	0.60
APOC1	activates	gene	0.60
APOC2	activates	gene	0.60
SOAT1	activates	gene	0.60
ABCA2	activates	gene	0.60
PSEN2	regulates	gene	0.60
TAU	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning APOC3 in their description or question text

No additional research found