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gene 891 words KG: LRP8
Contents

LRP8 Gene

🧬 Gene Info
Gene SymbolLRP8
Chromosome1p31.3
Protein TypeReceptor
FunctionNeuronal migration: Reelin-LRP8/Dab1 signaling regulates cortical lamination
Amino Acids870 aa
Exons31
PathwaysCardiovascular Homeostasis
Ensembl IDENSG00000157193
GeneCardsLRP8
Human Protein AtlasLRP8
Associated DiseasesAging, Als, Alzheimer, Atherosclerosis, Cancer
InteractionsABCA1, abca2, ABCA2, AGING, AKT, APOA1
KG Connections188 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (17)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74CYP46A1 Overexpression Gene Therapy
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedPerivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (13)

Exercise-BDNF-Mitophagy Biomarker Study in PD
experiment · KG edge: associated_withABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activatesABCA2 Gene - ATP Binding Cassette Subfamily A Member 2
gene · KG edge: activatesAPOA1 Gene
gene · KG edge: activatesAPOC1 Gene — Apolipoprotein C-I
gene · KG edge: activates

Knowledge Graph (12 edges)

LRP8 associated_with LRP5
LRP8 associated_with LRP1
LRP8 associated_with LRP2
LRP8 associated_with LRP1B
LRP8 associated_with LRP4
LRP8 associated_with PAH
LRP8 associated_with LDLR
LRP1B associated_with LRP8
PAH associated_with LRP8
LRP4 associated_with LRP8

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