| Gene Symbol | JAK2 |
| Aliases | Page for JAK2 Gene |
| Chromosome | 9p24.1 |
| Protein Type | Receptor |
| Function | is a critical non-receptor tyrosine kinase that mediates cytokine receptor signaling and plays essential roles in immune regulation, hematopoiesis, and cellular stress responses. |
| Primary Expression | neurons, astrocytes, microglia, and oligodendrocytes, where it participates in neuroinflammation, synaptic |
| Molecular Weight | 130 kDa |
| Amino Acids | 1132 aa |
| Pathways | JAK-STAT, JAK-STAT pathway |
| GeneCards | JAK2 |
| Human Protein Atlas | JAK2 |
| Associated Diseases | aging, Als, Alzheimer, APOPTOSIS, Autoimmune |
| Known Drugs/Compounds | AG490, BARICITINIB, curcumin, Curcumin, CURCUMIN, dasatinib |
| Interactions | ABCG2, ABL1, ABL2, AGING, Akt, AKT |
| KG Connections | 1039 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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