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mechanism 2,596 words KG: JAK
Contents

JAK-STAT and Cytokine Signaling in 4R-Tauopathies

⚙ Mechanism Info
NameJAK
Key Genes/ProteinsABCB1, ABCG2, ABL1, ACHE, AD, AD RISK GENES
Related DiseasesAddiction, aging, Aging
Related PathwaysAdaptive Immunity, Akt
Linked Hypotheses3 hypotheses

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Knowledge Graph

Related Hypotheses (30)

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Score: 0.38SASP-Mediated Complement Cascade Amplification
Score: 0.91Purinergic Signaling Polarization Control
Score: 0.71Mechanosensitive Ion Channel Reprogramming
Score: 0.70Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67

Related Analyses (28)

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Related Experiments (7)

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validation · proposed · Score: 0.45Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45

See Also (15)

Retinal Degeneration Pathway in Neurodegeneration
mechanism · Pages share 6 hypothesesgp130/IL-6 Family Cytokine Signaling in Neurodegenerati
mechanism · Pages share 6 hypothesesIL-1 Signaling Pathway in Neurodegeneration
mechanism · Pages share 6 hypothesesMicroglial Priming Pathway in Neurodegeneration
mechanism · Pages share 6 hypothesesDown Syndrome Neurodegeneration Pathway
mechanism · Pages share 6 hypotheses

Knowledge Graph (12 edges)

IL6 activates JAK
JAK activates STAT3
JAK regulates CHROMATIN
JAK regulates GENE_EXPRESSION
JAK causes Alzheimer's disease
SOCS inhibits JAK
JAK associated_with JAK1
JAK associated_with JAK2
JAK associated_with STAT1
JAK associated_with MAPK

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