concept

INSULIN RECEPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INSULIN RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

124Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	INSULIN RECEPTOR

Pathway Diagram

graph TD
    INSULIN_RECEPTOR["INSULIN RECEPTOR"]
    INSULIN_RECEPTOR -->|"mediates"| PI3K_Inhibitor_Resistance["PI3K Inhibitor Resistance"]
    INSULIN_RECEPTOR -->|"interacts"| RNA_polymerase_II["RNA polymerase II"]
    INSULIN_RECEPTOR -->|"interacts"| HCF1["HCF1"]
    INSULIN_RECEPTOR -->|"causes"| Insulin_Resistance["Insulin Resistance"]
    INSULIN_RECEPTOR -->|"inhibits"| Diabetes["Diabetes"]
    INSULIN_RECEPTOR -->|"inhibits"| Alzheimer["Alzheimer"]
    INSULIN_RECEPTOR -->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    Metformin["Metformin"] -->|"downregulates"| INSULIN_RECEPTOR
    INSR["INSR"] -->|"encodes"| INSULIN_RECEPTOR
    insulin["insulin"] -->|"activates"| INSULIN_RECEPTOR
    PKC["PKC"] -->|"target for"| INSULIN_RECEPTOR
    PIK3CA["PIK3CA"] -->|"target for"| INSULIN_RECEPTOR
    PI3K["PI3K"] -->|"inhibits"| INSULIN_RECEPTOR
    MTOR["MTOR"] -->|"target for"| INSULIN_RECEPTOR
    VGLUT1["VGLUT1"] -->|"inhibits"| INSULIN_RECEPTOR

Outgoing (57)

Target	Relation	Type	Str
insulin signaling	activates	pathway	0.90
neural stem cells	expressed_in	cell_type	0.80
RNA polymerase II	interacts_with	protein	0.70
neurodegeneration	associated_with	disease	0.70
blood-brain barrier	expressed_in	brain_region	0.70
diabetes	associated_with	disease	0.70
HCF1	interacts_with	protein	0.70
Insulin Resistance	causes	phenotype	0.70
brain-specific antibody transport	mediates	mechanism	0.70
hippocampus	expressed_in	brain_region	0.60
neurons	expressed_in	cell_type	0.60
astrocytes	expressed_in	cell_type	0.60
Diabetes	inhibits	disease	0.60
Alzheimer	inhibits	disease	0.60
Alzheimer	protects_against	disease	0.60
Als	protects_against	disease	0.60
Alzheimer	activates	disease	0.60
Als	activates	disease	0.60
Ferroptosis	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Diabetes	expressed_in	disease	0.60
Diabetes	activates	disease	0.60
Parkinson	activates	disease	0.60
Epilepsy	activates	disease	0.60
Obesity	activates	disease	0.60
Alzheimer	contributes_to	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Diabetes	therapeutic_target	disease	0.60
Neuropathy	therapeutic_target	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Aging	expressed_in	disease	0.60
Dementia	expressed_in	disease	0.60
Als	contributes_to	disease	0.60
Dementia	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Neuroinflammation	causes	disease	0.60
Mitochondrial Function	contributes_to	pathway	0.55
Pi3K/Akt	contributes_to	pathway	0.55
Wnt	regulates	pathway	0.55
Insulin Signaling	therapeutic_target	pathway	0.55
Lipid Metabolism	therapeutic_target	pathway	0.55
Blood-Brain Barrier	therapeutic_target	pathway	0.55
Mapk	therapeutic_target	pathway	0.55
Mtor	therapeutic_target	pathway	0.55
Insulin Signaling	activates	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Pi3K/Akt	therapeutic_target	pathway	0.55
Apoptosis	therapeutic_target	pathway	0.55
Autophagy	contributes_to	pathway	0.55

Incoming (67)

Source	Relation	Type	Str
INSR	encodes	gene	0.70
insulin	activates	drug	0.70
Alzheimer's disease	involves	disease	0.70
spinal muscular atrophy	involves	disease	0.60
FNDC5	activates	gene	0.60
PI3K	activates	gene	0.60
TAU	phosphorylates	gene	0.60
AKT	activates	gene	0.60
TAU	activates	gene	0.60
TAU	contributes_to	gene	0.60
MTOR	contributes_to	gene	0.60
TAU	protects_against	gene	0.60
TAU	causes	gene	0.60
neurodegeneration	involves	disease	0.60
BACE1	activates	gene	0.60
BACE1	expressed_in	gene	0.60
BACE1	inhibits	gene	0.60
BACE1	regulates	gene	0.60
PERICYTE	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
INSR	expressed_in	gene	0.60
AGING	expressed_in	gene	0.60
EXERCISE	activates	gene	0.60
PARKINSON	activates	gene	0.60
EPILEPSY	activates	gene	0.60
AMYLOID	phosphorylates	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
AMYLOID	contributes_to	gene	0.60
IRS1	inhibits	gene	0.60
IGF-1	contributes_to	gene	0.60
AUTOPHAGY	contributes_to	gene	0.60
GSK3	regulates	gene	0.60
WNT	regulates	gene	0.60
AMYLOID	protects_against	gene	0.60
IRS1	regulates	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
IGF-1	regulates	gene	0.60
ASTROCYTES	activates	gene	0.60
VGLUT1	inhibits	gene	0.60
AKT	protects_against	gene	0.60
MTOR	protects_against	gene	0.60
BACE1	regulates	gene	0.60
CLUSTERIN	activates	gene	0.60
CLU	regulates	gene	0.60
TREM2	implicated_in	gene	0.60
PI3K	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the actual quantitative contribution of FcRn-mediated transcytosis to BB

neuropharmacology | 2026-04-12 | 12 hypotheses Top: 0.585

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the actual quantitative contribution of FcRn-mediated transcytosis to BB

closed · Rounds: 6 · Score: 0.91 · 2026-04-12

Related Research

Hypotheses and analyses mentioning INSULIN RECEPTOR in their description or question text

No additional research found