protein 660 words KG: HES1PROTEIN
Contents

HES1 (Hairy and Enhancer of Split 1) Protein

🔬 Protein Info
Gene SymbolHES1PROTEIN
Chromosome3q29.
Protein TypeTranscription Factor
Functionis a protein encoded by the HES1 gene that hes1 is a key notch signaling effector:.
Molecular Weight30 kDa
Amino Acids280 aa
GeneCardsHES1PROTEIN
Human Protein AtlasHES1PROTEIN
Notch Signaling PathwayPrimary activation pathway for HES1
RBPJCo-factor required for HES1 transcriptional activation
HES3, HES5, HES7Related bHLH repressor proteins with partially overlapping functions
Neural Progenitor CellsPrimary cells regulated by HES1
Associated Diseasesneurodegeneration
InteractionsALS, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS, AND
KG Connections75 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (11)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Alpha-Synuclein Seeding Assays (RT-QuIC and PMCA)
biomarker · Pages share 3 hypotheses
IL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 3 hypotheses
Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses
Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

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