gene

HES5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HES5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections

0Hypotheses

0Analyses

17Outgoing

7Incoming

0Experiments

0Debates

Summary

HES5 is a basic helix-loop-helix transcription factor, key effector of Notch signaling, involved in neural stem cell maintenance and neurogenesis

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🧬 Gene Info

Gene Symbol	HES5
Full Name	Hairy and Enhancer of Split 5
Chromosome	1p36.32
Protein Family	HES family (bHLH transcription factor)
Protein Type	Transcription Factor
Function	is a basic helix-loop-helix (bHLH) transcription factor that functions as a transcriptional repressor and serves as a key effector of the Notch signaling pathway.
Primary Expression	the ventricular and subventricular zones, where neural stem cells reside
Amino Acids	199 aa
Pathways	Notch signaling, Notch
UniProt ID	[Q5JT76](https://www.uniprot.org/uniprot/Q5JT76)
Ensembl ID	ENSG00000197921
OMIM	604527
GeneCards	HES5
Human Protein Atlas	HES5
Subventricular zone (SVZ)	Neural stem cells
Associated Diseases	neurodegeneration
Interactions	C-FOS, CYTOKINES, DEPRESSION, FOS, IFN, IL-6
KG Connections	24 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HES5 Gene

gene · 1471 words

→

Pathway Diagram

graph TD
    HES5["HES5"]
    Aging{"Aging"}
    HES5 -->|"expressed in"| Aging
    Ms{"Ms"}
    HES5 -->|"expressed in"| Ms
    SOX2["SOX2"]
    HES5 -->|"expressed in"| SOX2
    Epigenetic(["Epigenetic"])
    HES5 -->|"expressed in"| Epigenetic
    neurodegeneration["neurodegeneration"]
    HES5 -->|"implicated in"| neurodegeneration
    style HES5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
Aging	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Depression	activates	disease	0.65
Parkinson	activates	disease	0.65
Aging	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
SOX2	expressed_in	gene	0.60
Epigenetic	expressed_in	pathway	0.60
Notch	expressed_in	pathway	0.60
TNF-Α	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
DEPRESSION	activates	gene	0.60
IFN	activates	gene	0.60
C-FOS	activates	gene	0.60
HES1	expressed_in	gene	0.60

Incoming (7)

Source	Relation	Type	Str
PARKINSON'S DISEASE	activates	gene	0.60
CYTOKINES	activates	gene	0.60
PARKINSON	activates	gene	0.60
IL-6	activates	gene	0.60
TNF	activates	gene	0.60
FOS	activates	gene	0.60
NOTCH1	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HES5 in their description or question text

No additional research found