gene

TFAP4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TFAP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

4Outgoing

6Incoming

0Experiments

0Debates

Summary

TFAP4 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, implicated in. Associated with Aging, Cardiovascular, Coronary Artery Disease. Connected to 11 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TFAP4
Full Name	Transcription Factor AP-4
Chromosome	16p13.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Cerebral cortex, Hippocampus, Cerebellum, Widespread
Molecular Weight	71 kDa
Amino Acids	641 aa
UniProt ID	Q01658
NCBI Gene ID	7023
Ensembl ID	ENSG00000130247
OMIM	601681
GeneCards	TFAP4
Human Protein Atlas	TFAP4
Basic DNA-binding domain	Recognizes the CAGTGT consensus sequence
Leucine zipper dimerization domain	Enables homodimer and heterodimer formation with other bZIP proteins
Associated Diseases	neurodegeneration
KG Connections	10 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TFAP4 — AlphaFold Q01658 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TFAP4 — Transcription Factor AP-4

gene · 671 words

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TFAP4 Protein

protein · 768 words

→

Pathway Diagram

graph TD
    TFAP4["TFAP4"]
    Coronary_Artery_Disease{"Coronary Artery Disease"}
    TFAP4 -->|"therapeutic_target"| Coronary_Artery_Disease
    Longevity{"Longevity"}
    TFAP4 -->|"therapeutic_target"| Longevity
    Aging{"Aging"}
    TFAP4 -->|"therapeutic_target"| Aging
    Cardiovascular{"Cardiovascular"}
    TFAP4 -->|"therapeutic_target"| Cardiovascular
    FGFR3["FGFR3"]
    FGFR3 -->|"associated_with"| TFAP4
    NOX4["NOX4"]
    NOX4 -->|"associated_with"| TFAP4
    TCF7L2["TCF7L2"]
    TCF7L2 -->|"associated_with"| TFAP4
    HIF1A["HIF1A"]
    HIF1A -->|"associated_with"| TFAP4
    GENES["GENES"]
    GENES -->|"therapeutic_target"| TFAP4
    AGING["AGING"]
    AGING -->|"therapeutic_target"| TFAP4
    neurodegeneration["neurodegeneration"]
    TFAP4 -->|"implicated_in"| neurodegeneration

Outgoing (4)

Target	Relation	Type	Str
Coronary Artery Disease	therapeutic_target	disease	0.65
Longevity	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65

Incoming (6)

Source	Relation	Type	Str
GENES	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
FGFR3	associated_with	gene	0.60
NOX4	associated_with	gene	0.60
TCF7L2	associated_with	gene	0.60
HIF1A	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TFAP4 in their description or question text

No additional research found