gene

PPP2CB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP2CB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

16Outgoing

11Incoming

0Experiments

0Debates

Summary

PPP2CB Gene

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🧬 Gene Info

Gene Symbol	PPP2CB
Full Name	Protein Phosphatase 2 Catalytic Subunit Beta
Chromosome	8p12
Protein Type	Serine/Threonine Phosphatase
Function	PPP2CB encodes the beta isoform of the PP2A catalytic subunit.
Primary Expression	various tissues, including the brain, where it participates in neuronal signaling pathways[@xu2008]
Subcellular Localization	and substrate preferences. This modularity allows PP2A-Cβ to coordinate diverse cellular processes from protein synthesi
UniProt ID	[P62714](https://www.uniprot.org/uniprot/P62714)
Ensembl ID	ENSG00000104231
GeneCards	PPP2CB
Human Protein Atlas	PPP2CB
Associated Diseases	ALS
Interactions	Actin, AND, CRBN, DNAJB6, GAPDH, LC3B
KG Connections	27 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPP2CB Gene

gene · 625 words

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Pathway Diagram

graph TD
    PPP2CB["PPP2CB"]
    PPP2CB -->|"interacts"| Als["Als"]
    PPP2CB -->|"interacts"| ALS["ALS"]
    PPP2CB -->|"interacts"| Encephalitis["Encephalitis"]
    PPP2CB -->|"interacts"| CRBN["CRBN"]
    PPP2CB -->|"interacts"| UBE2N["UBE2N"]
    PPP2CB -->|"interacts"| RNA["RNA"]
    PPP2CB -->|"interacts"| DNAJB6["DNAJB6"]
    PPP2CB -->|"interacts"| Actin["Actin"]
    DNAJB6 -->|"interacts"| PPP2CB
    RNA -->|"interacts"| PPP2CB
    UBE2N -->|"interacts"| PPP2CB
    CRBN -->|"interacts"| PPP2CB
    AND["AND"] -->|"interacts"| PPP2CB

Outgoing (16)

Target	Relation	Type	Str
Als	interacts_with	disease	0.65
Encephalitis	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
PRKN	activates	gene	0.60
PTEN	activates	gene	0.60
PPP2R2B	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
RNA	interacts_with	gene	0.60
Actin	interacts_with	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
UBE2N	interacts_with	gene	0.60
CRBN	interacts_with	gene	0.60
ALS	associated_with	disease	0.60
DNAJB6	interacts_with	gene	0.60
Rb	interacts_with	protein	0.60
Proteins	interacts_with	protein	0.50

Incoming (11)

Source	Relation	Type	Str
UBE2N	interacts_with	gene	0.60
GAPDH	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
OPTN	activates	gene	0.60
PINK1	activates	gene	0.60
PPP2CA	activates	gene	0.60
LC3B	activates	gene	0.60
DNAJB6	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
CRBN	interacts_with	gene	0.60
AND	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP2CB in their description or question text

No additional research found