Contents

DHODH — Dihydroorotate Dehydrogenase

🧬 Gene Info

Gene Symbol	DHODH
Full Name	Dihydroorotate Dehydrogenase
Chromosome	16q22.2
Protein Type	Enzyme
Function	encodes a mitochondrial inner membrane enzyme that catalyzes the fourth step in de novo pyrimidine biosynthesis — the oxidation of dihydroorotate to orotate.
Primary Expression	Ubiquitous (mitochondrial inner membrane); enriched in metabolically active neurons
Molecular Weight	43 kDa
Amino Acids	395 aa
Exons	10
Pathways	Ferroptosis
UniProt ID	Q02127
NCBI Gene ID	1723
Ensembl ID	ENSG00000102967
OMIM	126064
GeneCards	DHODH
Human Protein Atlas	DHODH
Associated Diseases	ALS
Interactions	ACSL4, AMPK, ATF3, ATP, CANCER, FERROPTOSIS
KG Connections	66 knowledge graph edges
Databases	GeneCards HPA STRING

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