gene 666 words KG: DHCR24
Contents

DHCR24 Gene

🧬 Gene Info
Gene SymbolDHCR24
Full Name24-Dehydrocholesterol Reductase
Chromosome1p31.3
Protein FamilyFAD-dependent oxidoreductases
Protein TypeEnzyme
Functionencodes an enzyme involved in the final step of cholesterol biosynthesis, converting 24-dehydrocholesterol to cholesterol.
Primary Expressionthe brain and essential for neuronal survival
Subcellular LocalizationEndoplasmic reticulum, lipid rafts
Molecular Weight56 kDa
Amino Acids489 aa
PathwaysViral Uptake, epigenetic regulation, unfolded protein response
UniProt IDQ8N0Y2
NCBI Gene ID1719
Ensembl IDENSG00000116133
OMIM606417
GeneCardsDHCR24
Human Protein AtlasDHCR24
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, AMI, disease
Known Drugs/Compoundsrapamycin
InteractionsA2M, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APH1B, APOE
KG Connections110 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (11)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Glial Glycocalyx Remodeling Therapy
Score: 0.65

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

See Also (13)

acc-chronic-pain
cell_type · KG edge: expressed_in
Apoptosis in Neurodegeneration
entity · KG edge: interacts_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_with
A2M Gene
gene · KG edge: interacts_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NCSTN interacts_with DHCR24
FAS interacts_with DHCR24
TNF interacts_with DHCR24
LMNA interacts_with DHCR24
APH1B interacts_with DHCR24
APOE interacts_with DHCR24
IL6 interacts_with DHCR24
SREBF1 associated_with DHCR24
PSEN2 interacts_with DHCR24
A2M interacts_with DHCR24

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