drug

dasatinib

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about dasatinib: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

99Connections

0Hypotheses

1Analyses

50Outgoing

28Incoming

0Experiments

3Debates

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💊 Drug Info

Name	dasatinib
Key Genes/Proteins	ABL1, ABL2, AKT, APP, AQP4, BCL-2
Related Diseases	Alzheimer's disease, multiple sclerosis, neurodegeneration

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Dasatinib + Quercetin (D+Q) for Neurodegeneration

therapeutic · 1137 words

→

Pathway Diagram

graph TD
    dasatinib["dasatinib"] -->|"associated"| senolytic_therapy["senolytic_therapy"]
    style senolytic_therapy fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    dasatinib["dasatinib"] -.->|"inhibits"| PDGFRB["PDGFRB"]
    style PDGFRB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    dasatinib["dasatinib"] -.->|"inhibits"| ABL1["ABL1"]
    style ABL1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    dasatinib["dasatinib"] -.->|"inhibits"| ABL2["ABL2"]
    style ABL2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    dasatinib["dasatinib"] -.->|"inhibits"| CSF1R["CSF1R"]
    style CSF1R fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    dasatinib["dasatinib"] -.->|"inhibits"| senescent_cells["senescent cells"]
    style senescent_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    dasatinib["dasatinib"] -->|"treats"| epilepsy["epilepsy"]
    style epilepsy fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    CSF1R_1["CSF1R"] -->|"expressed in"| dasatinib["dasatinib"]
    style CSF1R_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style dasatinib fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (71)

Target	Relation	Type	Str
Senescent Human Fat Cell Progenitors	treats	cell_type	0.95
Cellular Senescence	inhibits	process	0.95
Cognitive Deficits	treats	phenotype	0.92
Alzheimer'S Disease	treats	disease	0.90
Senescent Cells	targets	cell_type	0.90
Anti-apoptotic pathways	inhibits	pathway	0.85
senescent cells	associated_with	cell_type	0.85
senescent cells	targets	cell_type	0.80
SENESCENT CELLS	targets	cell_type	0.80
PIK3CD	targets	gene	0.75
senolytic_therapy	associated_with	drug	0.75
senescence	modulates	pathway	0.75
ABL1	inhibits	gene	0.72
CSF1R	inhibits	gene	0.72
ABL2	inhibits	gene	0.72
PDGFRB	inhibits	gene	0.72
senescent cells	inhibits	cell_type	0.70
Alzheimer's disease	treats	disease	0.70
ABL1	targets	gene	0.60
CSF1R	targets	gene	0.60
EPOR	targets	gene	0.60
NTRK3	targets	gene	0.60
AKT	targets	gene	0.60
APP	targets	gene	0.60
multiple sclerosis	treats	disease	0.60
ETV6	targets	gene	0.60
SFN	targets	gene	0.60
neurodegeneration	treats	disease	0.60
PDGFRB	targets	gene	0.60
ABL2	targets	gene	0.60
JAK2	targets	gene	0.60
LOX	targets	gene	0.60
BCL-2	targets	gene	0.55
STING	targets	gene	0.55
AQP4	targets	gene	0.55
STROKE	associated_with	disease	0.50
T CELLS	associated_with	cell_type	0.50
ASTROCYTE	associated_with	cell_type	0.50
MICROGLIA	associated_with	cell_type	0.50
ROS	associated_with	phenotype	0.50
CORTEX	associated_with	brain_region	0.50
MMSE	associated_with	biomarker	0.50
APP	associated_with	gene	0.50
CLU	associated_with	gene	0.50
CR1	associated_with	gene	0.50
TAU	associated_with	protein	0.50
TNF	associated_with	gene	0.50
AQP4	associated_with	gene	0.50
STING	associated_with	gene	0.50
CGAS	associated_with	gene	0.50

Incoming (28)

Source	Relation	Type	Str
STING PATHWAY	inhibits	pathway	0.70
APP	treats	gene	0.65
SENESCENCE	associated_with	phenotype	0.50
OXIDATIVE STRESS	associated_with	phenotype	0.50
SYNAPTIC LOSS	associated_with	phenotype	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
ASTROCYTES	associated_with	cell_type	0.50
PHAGOCYTOSIS	associated_with	phenotype	0.50
CGAS-STING PATHWAY	associated_with	pathway	0.50
STING PATHWAY	associated_with	pathway	0.50
MICROGLIAL ACTIVATION	associated_with	phenotype	0.50
COGNITIVE DECLINE	associated_with	phenotype	0.50
EPILEPSY	targets	gene	0.50
SULFORAPHANE	associated_with	drug	0.45
DEMYELINATION	associated_with	phenotype	0.45
METFORMIN	associated_with	drug	0.45
MITOCHONDRIAL DYSFUNCTION	associated_with	phenotype	0.45
RAPAMYCIN	associated_with	drug	0.45
SYNAPTIC PLASTICITY	associated_with	phenotype	0.45
INFLAMMATION	associated_with	phenotype	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
AMYLOID	associated_with	protein	0.45
ENDOTHELIAL CELLS	associated_with	cell_type	0.45
RUXOLITINIB	associated_with	drug	0.45
ABL1	associated_with	gene	0.45
CSF1R	associated_with	gene	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
CSF1R	expressed_in	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 1.000

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

closed · Rounds: 4 · Score: 0.81 · 2026-04-23

Investigate the therapeutic potential of clearing senescent cells (senolytics) t

closed · Rounds: 4 · Score: 0.75 · 2026-04-16

Senescent cell clearance as neurodegeneration therapy

closed · Rounds: 3 · Score: 0.95 · 2026-04-04

Related Research

Hypotheses and analyses mentioning dasatinib in their description or question text

No additional research found