concept

STING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

1Hypotheses

0Analyses

50Outgoing

15Incoming

0Experiments

0Debates

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💡 Concept Info

Name	STING PATHWAY
Key Genes/Proteins	CGAS, HDAC3, IL6
Related Diseases	ALS, ALZHEIMER, ALZHEIMER'S DISEASE, CANCER, FERROPTOSIS

Pathway Diagram

graph TD
    STING_PATHWAY["STING PATHWAY"]
    STING_PATHWAY -->|"promotes"| inflammatory_cytokine_expressi["inflammatory cytokine expression"]
    STING_PATHWAY -->|"mediates"| Innate_Immune_Response["Innate Immune Response"]
    STING_PATHWAY -->|"activates"| Cortical_Motor_Neurons["Cortical Motor Neurons"]
    STING_PATHWAY -->|"activates"| Spinal_Motor_Neurons["Spinal Motor Neurons"]
    STING_PATHWAY -->|"regulates"| innate_immunity["innate immunity"]
    STING_PATHWAY -->|"promotes"| atherosclerosis["atherosclerosis"]
    STING_PATHWAY -->|"regulates"| apoptosis["apoptosis"]
    STING_PATHWAY -->|"regulates"| pyroptosis["pyroptosis"]
    DNA_Damage["DNA Damage"] -->|"activates"| STING_PATHWAY
    DNA_damage["DNA damage"] -->|"activates"| STING_PATHWAY
    cigarette_smoke["cigarette smoke"] -->|"activates"| STING_PATHWAY
    C9ORF72["C9ORF72"] -->|"activates"| STING_PATHWAY
    MTAP_deletion["MTAP deletion"] -->|"modulates"| STING_PATHWAY

Outgoing (60)

Target	Relation	Type	Str
Antitumor Immunity	activates	process	0.95
Vulnerable Neurons	activates	cell_type	0.95
Cytokine Storm	causes	phenotype	0.90
Innate Immune Response	mediates	process	0.90
Innate Immune Signaling	mediates	process	0.90
Cortical Motor Neurons	activates	cell_type	0.90
inflammatory cytokine expression	promotes	process	0.90
Spinal Motor Neurons	activates	cell_type	0.90
innate immunity	regulates	process	0.85
atherosclerosis	promotes	disease	0.80
necroptosis	regulates	phenotype	0.70
pyroptosis	regulates	phenotype	0.70
IMMUNE RESPONSE	regulates	phenotype	0.70
DASATINIB	inhibits	drug	0.70
apoptosis	regulates	phenotype	0.70
NEUROINFLAMMATION	regulates	phenotype	0.65
TFEB	activates	gene	0.65
MICROGLIA	activates	cell_type	0.65
SENESCENCE	treats	phenotype	0.65
CD8+ T CELLS	interacts_with	cell_type	0.65
NEUROINFLAMMATION	causes	phenotype	0.65
TBK1	activates	gene	0.65
NLRP3 INFLAMMASOME	activates	pathway	0.65
NEUROINFLAMMATION	treats	phenotype	0.65
IMMUNE RESPONSE	implicated_in	phenotype	0.55
DASATINIB	associated_with	drug	0.50
QUERCETIN	associated_with	drug	0.50
ISCHEMIA	associated_with	disease	0.50
HDAC3	associated_with	gene	0.50
TUMOR CELLS	associated_with	cell_type	0.50
PARKINSON	associated_with	disease	0.50
CD8+ T CELLS	associated_with	cell_type	0.50
T CELLS	associated_with	cell_type	0.50
PARKIN	associated_with	gene	0.50
ASTROCYTES	associated_with	cell_type	0.50
NEURON	associated_with	cell_type	0.45
NEURONS	associated_with	cell_type	0.45
MOTOR NEURONS	associated_with	cell_type	0.45
SENESCENCE	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45
INFLAMMATION	associated_with	phenotype	0.45
TBK1	associated_with	gene	0.45
TFEB	associated_with	gene	0.45
TUMOR GROWTH	associated_with	phenotype	0.45
CGAS	associated_with	gene	0.45
STING	associated_with	gene	0.45
CANCER	associated_with	disease	0.45
MACROPHAGE	associated_with	cell_type	0.45
MACROPHAGES	associated_with	cell_type	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45

Incoming (15)

Source	Relation	Type	Str
Stimuli-Responsive Nanoplatforms	activates	compound	0.95
DNA Damage	activates	process	0.90
DNA damage	activates	process	0.87
cigarette smoke	activates	phenotype	0.85
C9ORF72	activates	gene	0.85
MTAP deletion	modulates	gene	0.75
DIMETHYL FUMARATE	associated_with	drug	0.50
TUMOR MICROENVIRONMENT	associated_with	phenotype	0.50
NEURODEGENERATION	associated_with	phenotype	0.45
IMMUNE RESPONSE	associated_with	phenotype	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45
HUNTINGTON'S DISEASE	associated_with	disease	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
PANCREATIC CANCER	associated_with	disease	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
cGAS-STING Pathway Hyperactivation Mediates Tau Propagation	0.760	neurodegeneration	Gap 006 analysis (archived stub)

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN [PMID:38712164]	Unknown
The R136S mutation in the APOE3 gene confers resilience against tau pathology vi [PMID:40555238]	Unknown
Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer [PMID:39753133]	Hyde VR, Zhou C, Fernandez JR, Chatterje	Cell reports	2025
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senes [PMID:39353433]	Carling GK, Fan L, Foxe NR, Norman K, Wo	Neuron	2024
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflam [PMID:34782623]	["Jin Meihua", "Shiwaku Hiroki", "Tanaka	Nature communications	2021

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STING PATHWAY in their description or question text

No additional research found