protein

DRAM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DRAM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

19Outgoing

20Incoming

0Experiments

0Debates

Summary

DRAM1 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Carcinoma, Lupus, Ms. Connected to 34 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	DRAM1
Full Name	DNA Damage Regulated Autophagy Modulator 1
Chromosome	7q34
Function	DRAM1 is a lysosomal membrane protein that acts as a key regulator of autophagy, a cellular process critical for clearing misfolded proteins and damaged organelles.
Molecular Weight	37 kDa
Pathways	mTOR, mtor
UniProt ID	DRAM1
NCBI Gene ID	55332
Ensembl ID	ENSG00000138271
OMIM	610686
GeneCards	DRAM1
Human Protein Atlas	DRAM1
Associated Diseases	Lupus
Interactions	AMPK, AUTOPHAGY, SNAP29, STIM1, STX17, ULK1
KG Connections	39 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DRAM1 Gene

gene · 584 words

→

DRAM1 Protein

protein · 597 words

→

Pathway Diagram

graph TD
    DRAM1["DRAM1"]
    Carcinoma{"Carcinoma"}
    DRAM1 -->|"activates"| Carcinoma
    Ms{"Ms"}
    DRAM1 -->|"activates"| Ms
    STUB1["STUB1"]
    DRAM1 -->|"regulates"| STUB1
    VAMP8["VAMP8"]
    DRAM1 -->|"activates"| VAMP8
    Autophagy(["Autophagy"])
    DRAM1 -->|"interacts with"| Autophagy
    AUTOPHAGY["AUTOPHAGY"]
    DRAM1 -->|"interacts with"| AUTOPHAGY
    SNAP29["SNAP29"]
    DRAM1 -->|"activates"| SNAP29
    neurodegeneration["neurodegeneration"]
    DRAM1 -->|"implicated in"| neurodegeneration
    DNA["DNA"]
    DNA -->|"regulates"| DRAM1
    SNAP29 -->|"activates"| DRAM1
    STX17["STX17"]
    STX17 -->|"activates"| DRAM1
    VAMP8 -->|"activates"| DRAM1
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"regulates"| DRAM1
    style DRAM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

Target	Relation	Type	Str
Lupus	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
Autophagy	interacts_with	pathway	0.60
STUB1	regulates	gene	0.60
VAMP8	activates	gene	0.60
STIM1	interacts_with	gene	0.60
STIM1	activates	gene	0.60
ULK1	activates	gene	0.60
SNAP29	activates	gene	0.60
IFN	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
Immune Response	associated_with	pathway	0.60
Phagocytosis	associated_with	pathway	0.60
AUTOPHAGY	interacts_with	gene	0.60
Adaptive Immunity	associated_with	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
Parkinson's disease	activates	disease	0.60

Incoming (20)

Source	Relation	Type	Str
AMPK	activates	gene	0.60
ATG16L2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
CDKN1B	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
CYBB	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
LC3	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
STX17	activates	gene	0.60
VAMP8	activates	gene	0.60
UBIQUITIN	regulates	gene	0.60
DNA	regulates	gene	0.60
SNAP29	activates	gene	0.60
MTORC1	associated_with	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
DNA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DRAM1 in their description or question text

No additional research found