| Gene Symbol | CDK6 |
| Aliases | Cyclin-Dependent Kinase 6 |
| Protein Type | Serine/Threonine Kinase |
| Function | The CDK6 gene encodes Cyclin-Dependent Kinase 6, a 326-amino acid serine/threonine kinase |
| Primary Expression | gliomas, lymphomas, and carcinomas |
| Subcellular Localization | , including serine and threonine residues that can be targeted by upstream kinases |
| Molecular Weight | 37 kDa |
| Amino Acids | 326 aa |
| Ensembl ID | ENSG00000105810 |
| GeneCards | CDK6 |
| Human Protein Atlas | CDK6 |
| C-terminal regulatory region | Contains additional phosphorylation sites that modulate CDK6 activity and subcellular localization, including serine and threonine residues that can be targeted by upstream kinases. |
| Tyrosine-24 (Y24) | Inhibitory phosphorylation that can be reversed by CDKs. This site is targeted by Wee1 and Myt1 kinases. |
| Serine/Threonine sites | Additional regulatory phosphorylation sites in the C-terminal region. |
| Associated Diseases | Als, Cancer, Carcinoma, Tumor |
| Interactions | AKT, AMBRA1, AND, AUTOPHAGY, AUTOPHAGY-RELATED GENES, CANCER |
| KG Connections | 74 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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