concept

APOE Ε4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APOE Ε4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

182Connections

2Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

5Debates

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💡 Concept Info

Name	APOE Ε4
Key Genes/Proteins	ABCG1, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA
Related Diseases	Aging, ALS, Alzheimer, Alzheimer's Disease, Anxiety
Related Pathways	Amyloid

Pathway Diagram

graph TD
    APOE__4["APOE Epsilon4"]
    style APOE__4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    APOE__4 -->|"risk_factor_for"| Alzheimer_s_Disease["Alzheimer's Disease"]
    APOE__4 -.->|"inhibits"| Neuroprotection["Neuroprotection"]
    APOE__4 -->|"upregulates"| STING([STING])
    APOE__4 -.->|"biomarker for"| Alzheimer["Alzheimer"]
    APOE__4 -.->|"biomarker for"| Neuroinflammation["Neuroinflammation"]
    APOE__4 -.->|"biomarker for"| ALS["ALS"]
    APOE__4 -.->|"biomarker for"| Inflammation["Inflammation"]
    APOE__4 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    APOE__4 -->|"activates"| Dementia["Dementia"]
    NEUROINFLAMMATION([NEUROINFLAMMATION]) -.->|"biomarker for"| APOE__4
    CYTOKINES([CYTOKINES]) -.->|"biomarker for"| APOE__4
    IL9([IL9]) -.->|"biomarker for"| APOE__4
    PDGFRB([PDGFRB]) -.->|"biomarker for"| APOE__4
    AMYLOID([AMYLOID]) -.->|"biomarker for"| APOE__4
    NPTX1([NPTX1]) -.->|"biomarker for"| APOE__4
    CHI3L1([CHI3L1]) -.->|"biomarker for"| APOE__4
    AMYLOID_BETA([AMYLOID-BETA]) -.->|"biomarker for"| APOE__4
    INFLAMMATION([INFLAMMATION]) -.->|"biomarker for"| APOE__4
    NEFL([NEFL]) -.->|"biomarker for"| APOE__4

Outgoing (132)

Target	Relation	Type	Str
Alzheimer's disease	associated_with	disease	1.00
Alzheimer Disease	risk_factor_for	disease	0.95
amyloid-beta plaque deposition	promotes	process	0.93
Aβ aggregation	causes	mechanism	0.90
tau spreading	causes	mechanism	0.90
Alzheimer's disease	causes	disease	0.90
AD	risk_factor_for	disease	0.90
Alzheimer's Disease	risk_factor_for	disease	0.90
brain lipid metabolism	disrupts	pathway	0.90
cognitive impairment	causes	process	0.90
Alzheimer disease	risk_factor_for	disease	0.90
distinct genetic form of AD	causes	phenotype	0.90
late-onset Alzheimer's disease	associated_with	disease	0.90
cortical Aβ burden	causes	biomarker	0.90
NEUTROPHILS	interacts_with	cell_type	0.90
MICROGLIA	interacts_with	cell_type	0.90
cognitive decline	causes	pathway	0.90
SV2A	downregulates	protein	0.88
pS65-Ub	associated_with	biomarker	0.85
Age of Onset	modulates	phenotype	0.85
Neuroprotection	inhibits	process	0.85
STING	upregulates	protein	0.80
cerebral amyloid angiopathy	associated_with	disease	0.80
microglia	disrupts	cell_type	0.80
cognitive decline	associated_with	pathway	0.80
cerebral amyloid angiopathy burden	increases	pathology	0.70
p-tau217 normalization	delays	process	0.70
synaptic vulnerability	causes	mechanism	0.70
vascular dysfunction	causes	mechanism	0.70
microglial activation	causes	mechanism	0.70
Anxiety	protects_against	disease	0.65
Diabetes	protects_against	disease	0.65
Tumor	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Dementia	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
ALS	causes	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
CYP46A1	activates	gene	0.60

Incoming (50)

Source	Relation	Type	Str
ASTROCYTE	associated_with	gene	0.60
APOE	associated_with	gene	0.60
APOE4	activates	gene	0.60
PLCG2	interacts_with	gene	0.60
DNA	associated_with	gene	0.60
FGF2	biomarker_for	gene	0.60
IL4	biomarker_for	gene	0.60
TAU PATHOLOGY	biomarker_for	gene	0.60
GENES	activates	gene	0.60
CLU	associated_with	gene	0.60
ANXIETY	protects_against	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
IL9	biomarker_for	gene	0.60
PDGFRB	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
NPTX1	biomarker_for	gene	0.60
SQSTM1	associated_with	gene	0.60
CHI3L1	biomarker_for	gene	0.60
AMYLOID-BETA	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
NEFL	biomarker_for	gene	0.60
MDH1	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
CHIT1	biomarker_for	gene	0.60
TAU	biomarker_for	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
APOE	inhibits	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
APP	activates	gene	0.60
NLRP3	activates	gene	0.60
CGAS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
APP	inhibits	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
MICROGLIA	inhibits	gene	0.60
PSEN1	activates	gene	0.60
PSEN2	activates	gene	0.60
DEMENTIA	associated_with	gene	0.60
GENES	associated_with	gene	0.60
APOE	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
DNA	activates	gene	0.60
DEMENTIA	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE ε4 Drives Lipid Droplet Accumulation in a Unique Lipid-	0.685	Alzheimer disease	APOE ε4 Lipid Metabolism Differences in
APOE ε4-driven microglial lipid handling as proximal driver	0.626	neurodegeneration	Non-Neuronal Transcriptional Changes Pre