| Gene Symbol | AQP1 |
| Full Name | Aquaporin 1 |
| Chromosome | 7p14.3 |
| Protein Type | Channel |
| Target Class | Ion Channel |
| Function | encodes a water channel protein that facilitates rapid water transport across cell membranes. |
| Mechanism of Action | AQP1 functions as a water channel protein facilitating transmembrane water flux, with emerging evidence suggesting its involvement in neuroinflammatory processes and potential contribution to neuronal cell volume regulation and edema formation in neurodegenerative conditions. In the context of neurodegeneration, AQP1 may modulate neuronal and glial cell responses to oxidative stress, inflammation, and cellular metabolic perturbations, making it a potential strategic target for therapeutic intervention. |
| Primary Expression | the central nervous system, particularly in the choroid plexus, where it plays a critical role in [cerebrospinal fluid ( |
| Druggability | Low (0.39) |
| Clinical Stage | Approved |
| Molecular Weight | 28 kDa |
| Pathways | Angiogenesis, Complement, Epigenetic, Glycolysis, Immune Response |
| UniProt ID | P29972 |
| NCBI Gene ID | 358 |
| Ensembl ID | ENSG00000240583 |
| OMIM | 107700 |
| GeneCards | AQP1 |
| Human Protein Atlas | AQP1 |
| Associated Diseases | aging, Als, Alzheimer |
| Known Drugs/Compounds | H2O2, Hydrogen Peroxide |
| Interactions | AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, App |
| SciDEX Target | View Target Profile (6 clinical trials) |
| SciDEX Hypotheses | Osmotic Gradient Restoration via Selective AQP1 En |
| KG Connections | 294 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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