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gene 790 words KG: APH1B
Contents

APH1B Gene - Anterior Pharynx Defective 1 Homolog B

🧬 Gene Info
Gene SymbolAPH1B
Full NameAph-1 Homolog B, Gamma-Secretase Subunit
AliasesAPH-1B
Chromosome15q22.2
FunctionGamma-secretase complex subunit, cleaves APP and Notch
Subcellular Localization**Substrate Processing**: Contributes to the recognition and processing of various type I transmembrane protein substrat
Molecular Weight28.5 kDa
Amino Acids257
PathwaysGamma-secretase complex, Notch signaling, APP processing
UniProt IDQ8WW43
NCBI Gene ID83464
Ensembl IDENSG00000138613
OMIM607630
GeneCardsAPH1B
Human Protein AtlasAPH1B
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, AMI, disease
InteractionsA2M, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APH1A
KG Connections102 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (14)

CYP46A1 Overexpression Gene Therapy
Score: 0.92Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Apoptosis in Neurodegeneration
entity · KG edge: interacts_withAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_withA2M Gene
gene · KG edge: interacts_withDAPK1 Gene
gene · KG edge: interacts_withAPOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: interacts_with

Knowledge Graph (12 edges)

NCSTN interacts_with APH1B
FAS interacts_with APH1B
TNF interacts_with APH1B
LMNA interacts_with APH1B
APH1B interacts_with APOE
APH1B interacts_with IL6
APH1B interacts_with SREBF1
APH1B interacts_with PSEN2
APH1B interacts_with A2M
APH1B interacts_with DHCR24

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