gene

aph1a

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about aph1a: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

5Outgoing

2Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	APH1A
Aliases	Page for APH1A Gene, Page for APH1A Protein
Chromosome	1p36.22
Protein Family	Aph-1 family (gamma-secretase)
Function	### Gamma-Secretase Complex Component
Primary Expression	Brain (cerebral cortex, hippocampus, cerebellum), Heart, Liver, Kidney, Pancreas
Subcellular Localization	Endoplasmic reticulum, Golgi, plasma membrane
Molecular Weight	28.5 kDa
Amino Acids	257 aa
Pathways	notch, Notch signaling
UniProt ID	Q9Y6X0
Ensembl ID	ENSG00000144024
GeneCards	APH1A
Human Protein Atlas	APH1A
Associated Diseases	Alzheimer's Disease, Familial Alzheimer's Disease
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: aph1a — AlphaFold Q9Y6X0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

APH1A Gene - Anterior Pharynx Defective 1 Homolog A

gene · 980 words

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Pathway Diagram

flowchart TD
    APH1A["APH1A"] -.->|"inhibits"| APH1B["APH1B"]
    APH1A["APH1A"] -.->|"inhibits"| PSEN1["PSEN1"]
    APH1A["APH1A"] -.->|"inhibits"| PSEN2["PSEN2"]
    APH1A["APH1A"] -->|"implicated in"| neurodegeneration["neurodegeneration"]
    style APH1A fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style APH1B fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style PSEN1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style PSEN2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style neurodegeneration fill:#006494,stroke:#333,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:APH1A	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
APH1B	inhibits	gene	0.60
PSEN1	inhibits	gene	0.60
PSEN2	inhibits	gene	0.60

Incoming (2)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:APH1A	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning aph1a in their description or question text

No additional research found