gene

SLC1A5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC1A5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

28Outgoing

11Incoming

0Experiments

0Debates

Summary

SLC1A5 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Cancer, Leukemia, Tumor. Connected to 23 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SLC1A5
Full Name	Solute Carrier Family 1 Member 5
Chromosome	19q13.33
Protein Type	Transporter
Function	is a sodium-dependent neutral amino acid transporter critical for cellular uptake of glutamine, alanine, serine, and cysteine[@amino2017].
Primary Expression	many cancers where it supports rapid glutamine metabolism[@slc2020]
Molecular Weight	56 kDa
Amino Acids	541 aa
Pathways	mTOR pathway
UniProt ID	P52802
NCBI Gene ID	6510
Ensembl ID	ENSG00000105374
OMIM	109440
GeneCards	SLC1A5
Human Protein Atlas	SLC1A5
Associated Diseases	neurodegeneration
Interactions	ACC, ACLY, AUTOPHAGY, CANCER, DNA, DYRK1A
KG Connections	39 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC1A5 — AlphaFold P52802 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC1A5 Gene

gene · 1058 words

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Pathway Diagram

graph TD
    SLC1A5["SLC1A5
Glutamine Transporter"]
    STAT3["STAT3
Transcription Factor"]
    AUTOPHAGY_REG["AUTOPHAGY
Regulatory Gene"]
    MTORC1["MTORC1
Protein Complex"]
    MTOR_PATH["mTOR Pathway
Growth Signaling"]
    MITOCHONDRIA["MITOCHONDRIA
Energy Production"]
    OX_PHOS["Oxidative
Phosphorylation"]
    LYSOSOME["LYSOSOME
Cellular Degradation"]
    AUTOPHAGY_PATH["Autophagy
Pathway"]
    MYC["MYC
Oncogene"]
    NEURODEGENERATION["Neurodegeneration
Disease Process"]
    DNA_DAMAGE["DNA Damage
Cellular Stress"]
    GLUTAMINE["Glutamine
Amino Acid"]
    
    STAT3 -->|"transcriptionally regulates"| SLC1A5
    AUTOPHAGY_REG -->|"upregulates"| SLC1A5
    GLUTAMINE -->|"transported by"| SLC1A5
    SLC1A5 -->|"activates"| MTORC1
    SLC1A5 -->|"promotes"| MTOR_PATH
    SLC1A5 -->|"enhances"| MITOCHONDRIA
    SLC1A5 -->|"drives"| OX_PHOS
    SLC1A5 -->|"activates"| LYSOSOME
    SLC1A5 -->|"modulates"| AUTOPHAGY_PATH
    SLC1A5 -->|"regulates"| MYC
    SLC1A5 -->|"contributes to"| NEURODEGENERATION
    SLC1A5 -->|"inhibits repair of"| DNA_DAMAGE
    MTORC1 -->|"inhibits"| AUTOPHAGY_PATH
    
    style SLC1A5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style AUTOPHAGY_PATH fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style OX_PHOS fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style NEURODEGENERATION fill:#7d4200,stroke:#ff9800,stroke-width:2px
    style DNA_DAMAGE fill:#ef5350,stroke:#f44336,stroke-width:2px
    style STAT3 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style MYC fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style MTORC1 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px

Outgoing (28)

Target	Relation	Type	Str
Fibrosis	inhibits	disease	0.65
Leukemia	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
MYC	activates	gene	0.60
MYC	regulates	gene	0.60
Mtor	regulates	pathway	0.60
Autophagy	activates	pathway	0.60
SMAD3	inhibits	gene	0.60
MITOCHONDRIA	activates	gene	0.60
Mtor	activates	pathway	0.60
Invasion	activates	pathway	0.60
Tumor Microenvironment	therapeutic_target	pathway	0.60
Immunotherapy	activates	pathway	0.60
DNA	inhibits	gene	0.60
Oxidative Phosphorylation	activates	pathway	0.60
LYSOSOME	activates	gene	0.60
Stem Cell	activates	pathway	0.60
MTORC1	activates	gene	0.60
CANCER	activates	gene	0.60
LDHA	regulates	gene	0.60
Glycolysis	inhibits	pathway	0.60
TGF	inhibits	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
MTOR	regulates	gene	0.60
GLS1	regulates	gene	0.60
Rb	inhibits	protein	0.60

Incoming (11)

Source	Relation	Type	Str
STAT3	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ACC	activates	gene	0.60
ACLY	activates	gene	0.60
GLUT1	activates	gene	0.60
LDHA	activates	gene	0.60
PKM2	activates	gene	0.60
FASN	activates	gene	0.60
GLS	activates	gene	0.60
HK2	activates	gene	0.60
DYRK1A	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC1A5 in their description or question text

No additional research found