gene

NF-ΚB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF-ΚB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5441Connections

15Hypotheses

12Analyses

50Outgoing

50Incoming

0Experiments

20Debates

Summary

NF-ΚB is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with ALS, Aging, Als. Connected to 2074 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	NF
Function	Nf Κb P105 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	NF
Human Protein Atlas	NF
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety, Atherosclerosis
Known Drugs/Compounds	Nicotiflorin, Sphingosine-1-Phosphate, Ursolic Acid, β-D-Manno-Heptose 1,7-bisphosphate
Interactions	ABCA1, ABCG1, ABIN1, ACE, ACHE, ACLY
KG Connections	2746 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    NF__B["NF-KappaB"] -->|"therapeutic target"| Cardiovascular["Cardiovascular"]
    NF__B["NF-KappaB"] -->|"therapeutic target"| Inflammation["Inflammation"]
    NF__B["NF-KappaB"] -->|"therapeutic target"| Als["Als"]
    NF__B["NF-KappaB"] -->|"therapeutic target"| Ms["Ms"]
    NF__B["NF-KappaB"] -->|"therapeutic target"| Tumor["Tumor"]
    NF__B["NF-KappaB"] -->|"therapeutic target"| Autoimmune["Autoimmune"]
    STAT3["STAT3"] -->|"associated"| NF__B["NF-KappaB"]
    MTOR["MTOR"] -->|"therapeutic target"| NF__B["NF-KappaB"]
    CD40["CD40"] -->|"therapeutic target"| NF__B["NF-KappaB"]
    CYTOKINES["CYTOKINES"] -->|"therapeutic target"| NF__B["NF-KappaB"]
    style NF__B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2187)

Target	Relation	Type	Str
NF-ΚB	encodes	protein	0.00
Cancer	activates	disease	1.00
Als	therapeutic_target	disease	1.00
TNF-Α	inhibits	gene	1.00
IL-6	inhibits	gene	1.00
Inflammation	therapeutic_target	disease	1.00
Tumor	inhibits	disease	1.00
Neurodegeneration	activates	disease	1.00
Als	inhibits	disease	1.00
NEURODEGENERATIVE DISEASES	activates	gene	1.00
Tumor	therapeutic_target	disease	1.00
AKT	regulates	gene	1.00
Pi3K/Akt	regulates	pathway	1.00
Nf-Κb	regulates	pathway	1.00
Apoptosis	activates	pathway	1.00
Nf-Κb	activates	pathway	1.00
Diabetes	activates	disease	1.00
Glycolysis	activates	pathway	1.00
Tumor	activates	disease	1.00
IL-6	activates	gene	1.00
Mapk	inhibits	pathway	1.00
NEURON	activates	gene	1.00
GENES	regulates	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
Autoimmune	activates	disease	1.00
Inflammation	inhibits	disease	1.00
Autoimmune	therapeutic_target	disease	1.00
CANCER	inhibits	gene	1.00
Cardiovascular	therapeutic_target	disease	1.00
Nf-Κb	therapeutic_target	pathway	1.00
Inflammation	activates	disease	1.00
Cancer	inhibits	disease	1.00
Nf-Κb	inhibits	pathway	1.00
Mtor	inhibits	pathway	1.00
Atherosclerosis	inhibits	disease	1.00
Cardiovascular	activates	disease	1.00
Autophagy	inhibits	pathway	1.00
CANCER	activates	gene	1.00
Als	activates	disease	1.00
TNF-Α	activates	gene	1.00
Nf-Κb	interacts_with	pathway	1.00
Apoptosis	regulates	pathway	1.00
Mapk	activates	pathway	1.00
Mtor	activates	pathway	1.00
Carcinoma	activates	disease	1.00
P53	activates	gene	1.00
Immune Response	activates	pathway	1.00
MTOR	regulates	gene	1.00
AKT	activates	gene	1.00
Inflammation	treats	disease	1.00

Incoming (3254)

Source	Relation	Type	Str
NF-ΚB	encodes	gene	0.00
OXIDATIVE STRESS	inhibits	gene	1.00
ERK	inhibits	gene	1.00
OXIDATIVE STRESS	inhibits	gene	1.00
Cardiovascular	activates	disease	1.00
APOPTOSIS	activates	gene	1.00
Cancer	associated_with	disease	1.00
CANCER	associated_with	gene	1.00
Autoimmune	activates	disease	1.00
NEURODEGENERATION	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
CANCER	activates	gene	1.00
Infection	activates	disease	1.00
PARKINSON	activates	gene	1.00
APOPTOSIS	inhibits	gene	1.00
NLRP3	activates	gene	1.00
TNF	regulates	gene	1.00
Obesity	inhibits	disease	1.00
NRF2	inhibits	gene	1.00
Tumor	activates	disease	1.00
AUTOPHAGY	regulates	gene	1.00
APOPTOSIS	regulates	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
PARKINSON	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
ALZHEIMER	activates	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
AMPK	activates	gene	1.00
MTOR	regulates	gene	1.00
CYTOKINES	regulates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
CYTOKINES	inhibits	gene	1.00
Alzheimer	activates	disease	1.00
NF-ΚB	activates	gene	1.00
Tumor	regulates	disease	1.00
CANCER	inhibits	gene	1.00
CYTOKINES	regulates	gene	1.00
PI3K	therapeutic_target	gene	1.00
MTOR	inhibits	gene	1.00
Neurodegeneration	activates	disease	1.00
INFLAMMATION	inhibits	gene	1.00
Autoimmune	therapeutic_target	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	1.00
CYTOKINES	therapeutic_target	gene	1.00
NF-ΚB	therapeutic_target	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
CYTOKINES	therapeutic_target	gene	1.00
Inflammation	associated_with	disease	1.00

Targeting Hypotheses (15)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SCFA Deficiency Drives Microglial Hyperactivation via GPR43/	0.728	neurodegeneration	How does gut microbiome dysbiosis contri
TLR4/MyD88/NF-κB Axis Blockade to Interrupt LPS-Mediated Gut	0.703	neurodegeneration	How do gut microbiome-derived metabolite
TNF-α/NF-κB Axis Upregulates P2RY12 in VSMCs	0.650	neurodegeneration	What determines P2RY12 receptor expressi
S100B as Active Pathogenic BBB-Disrupting Signal via RAGE/NF	0.647	-	Blood-brain barrier permeability changes
LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target	0.619	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M

TNF-α–C1r/C1s Bridge Between NF-κB and Classical Complement	0.600	neuroinflammation	How does sevoflurane-induced NF-κB activ
Astrocyte-Derived EV miR-146a-5p Mimics as Erasers of Traine	0.588	neuroinflammation	What specific astrocyte-derived factors
αvβ3 Integrin-FAK-SYK-CARD9/NF-κB Pathway	0.580	neuroinflammation	What molecular mechanisms mediate SPP1-i
Microglial Priming via NF-κB-Dependent DAM Phenotype and Com	0.580	neuroinflammation	How does sevoflurane-induced NF-κB activ
Direct NF-κB Transcriptional Regulation of C1q Genes in Micr	0.570	neuroinflammation	How does sevoflurane-induced NF-κB activ
Dual NF-κB/MMP Inhibition Strategy	0.554	-	Blood-brain barrier tight junction disru
CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macr	0.535	neurodegeneration	How do perivascular cells specifically r
GATA4 Stabilization and NF-κB Co-activation Identifies Senes	0.520	neurodegeneration	How can senescent microglia be molecular
YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1	0.492	neurodegeneration	How do perivascular cells specifically r
Convergent NF-κB enhancers across diverse priming stimuli sh	0.380	Alzheimer's disease	Do different priming stimuli require dis

Mentioning Analyses (12)

Scientific analyses that reference this entity

How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegen

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.728

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

neuropharmacology | 2026-04-25 | 4 hypotheses Top: 0.659

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

molecular biology | 2026-04-17 | 10 hypotheses Top: 0.445

What determines the GPX4/ACSL4 balance that switches microglia from protective t

immunology | 2026-04-15 | 0 hypotheses

What is the temporal sequence of TREM2 signaling transition from protective to i

neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.670

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Chrysophanol Attenuates Cognitive Impairment, Neuroinflammation, and Oxidative S [PMID:40728692]	Khan JZ, Zainab SR, Alattar A	Neurochem Res	2025
Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR [PMID:38184025]	Unknown	Journal of ethnopharmacology	2024
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microgl [PMID:37466915]	Sun W, Wang Q, Zhang R, Zhang N	Food & function	2023
NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via [PMID:37137264]	Ibrahim Weam W; Skalicka-Woźniak K	International immunopharmacolo	2023
Microglia clear neuron-released α-synuclein via selective autophagy and prevent [PMID:32170061]	Choi I, Zhang Y, Seegobin SP	Nat Commun	2020
Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction throug [PMID:32622362]	Mondal A, Bose D, Saha P	J Neuroinflammation	2020
RETRACTED: Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammat [PMID:30884890]	["Muhammad T", "Ikram M", "Ullah R", "Re	Nutrients	2019

Debates (20)

Multi-agent debates referencing this entity

Extended debate: Metabolic Reprogramming to Reverse Senescence

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Debate: TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation

closed · Rounds: 4 · Score: 0.59 · 2026-04-27

Debate: SCFA Deficiency Drives Microglial Hyperactivation via GPR43/NF-κB Dysreg

closed · Rounds: 4 · Score: 0.13 · 2026-04-27

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

closed · Rounds: 4 · Score: 0.44 · 2026-04-27