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gene 2,283 words KG: CASP3
Contents

CASP3 Gene

🧬 Gene Info
Gene SymbolCASP3
Full NameCaspase 3
Chromosome4q34
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight20 kDa
Amino Acids277 aa
PathwaysAkt, Apoptosis, Autophagy, Epigenetic, Glycolysis
UniProt ID[P42574](https://www.uniprot.org/uniprot/P42574)
Ensembl IDENSG00000164305
GeneCardsCASP3
Human Protein AtlasCASP3
Associated DiseasesAging, Als, Alzheimer, Alzheimer_disease, Alzheimer's disease
Known Drugs/CompoundsANTHOCYANINS, aristolochic_acids, Atbc, berberine, BERBERINE, Bpmc
InteractionsABP, ACHE, ACTB, AKT, AKT1, AKT1S1
KG Connections1487 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (27)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75APOE Isoform Expression Across Glial Subtypes
Score: 0.74PARP1 Inhibition Therapy
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Lysosomal Positioning Dynamics Modulation
Score: 0.69CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.67Nucleolar Stress Response Normalization
Score: 0.65DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
pg 1/2Next →

Related Analyses (7)

Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completedSynaptic pruning by microglia in early AD
neurodegeneration · archivedEpigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedCell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived

See Also (5)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_targetACTB Gene
gene · KG edge: associated_withAKT1 Gene
gene · KG edge: inhibitsAIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_withAging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: expressed_in

Knowledge Graph (12 edges)

CASP3 encodes CASPASE3
OPTN interacts_with CASP3
CASP3 regulates AKT1
CASP3 regulates CALCOCO2
CASP3 regulates CGAS
CASP3 regulates CFTR
CASP3 interacts_with SQSTM1
CASP3 interacts_with RPS6KB1
CASP3 interacts_with GRB2
CASP3 interacts_with RHEB

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