| Gene Symbol | TFE3 |
| Function | is a member of the MiT/TFE family of basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factors, alongside TFEB, MITF, and TFEC. |
| Primary Expression | neurons, microglia, astrocytes, and oligodendrocytes - Double |
| Molecular Weight | 59.5 kDa |
| Amino Acids | 575 aa |
| Pathways | mTOR, mtor |
| Ensembl ID | ENSG00000068323 |
| GeneCards | TFE3 |
| Human Protein Atlas | TFE3 |
| Lysosomal hydrolases | CTSD, CTSB, CTSL, HEXA, HEXB, GLA |
| Lysosomal membrane proteins | LAMP1, LAMP2, MCOLN1, ATP6V0D1, ATP6V1H |
| Autophagy regulators | BECN1, ATG9A, ATG16L1, WIPI1, ULK1 |
| Lipid catabolism | PPARGC1A, LIPA, ASAH1 |
| Macroautophagy | Upregulation of ATG genes for autophagosome formation |
| Chaperone-mediated autophagy (CMA) | Induction of LAMP2A and HSC70 |
| Associated Diseases | ALS, Alzheimer, Kidney Cancer, Multiple Sclerosis, neurodegeneration, Parkinson |
| Known Drugs/Compounds | rapamycin |
| Interactions | Actin, AGING, AKT, AKT1, AKT1S1, AKT2 |
| SciDEX Hypotheses | Selective TFEB Cofactor Enhancement |
| KG Connections | 610 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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