| Stage I | NFT formation begins in the transentorhinal region |
| Stage II | Spread to the entorhinal cortex and CA1 of hippocampus |
| Stage III | Involvement of limbic structures |
| Stage IV | Extension to temporal isocortex |
| Stage V | Neocortical involvement (sparing of primary motor/sensory areas) |
| Stage VI | Complete neocortical involvement including primary regions |
| Vascular comorbidities | Accelerated cognitive decline |
| Metabolic syndrome | Faster progression |
| Low education/cognitive reserve | Faster decline |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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