concept

CXCL9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCL9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

126Connections

0Hypotheses

1Analyses

50Outgoing

49Incoming

0Experiments

1Debates

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💡 Concept Info

Name	CXCL9
Key Genes/Proteins	ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, AUTOPHAGY
Related Diseases	Als, ALS, Alzheimer, Alzheimer's disease, Alzheimer's Disease
Related Pathways	Apoptosis, Autophagy

Pathway Diagram

graph TD
    CXCL9["CXCL9"]
    CXCL9 -->|"binds"| CXCR3["CXCR3"]
    CXCL9 -->|"involved_in"| Th1_Type_Response["Th1-Type Response"]
    CXCL9 -->|"involved_in"| Neuroinflammation["Neuroinflammation"]
    CXCL9 -->|"correlates_with"| T_Cell_Infiltration["T Cell Infiltration"]
    CXCL9 -->|"activates"| Inflammation["Inflammation"]
    CXCL9 -->|"expressed in"| Alzheimer["Alzheimer"]
    CXCL9 -->|"expressed in"| Multiple_Sclerosis["Multiple Sclerosis"]
    CXCL9 -->|"inhibits"| ALS["ALS"]
    IFNG["IFNG"] -->|"upregulates"| CXCL9
    IFN_GAMMA["IFN_GAMMA"] -->|"activates"| CXCL9
    CXCR3 -->|"expressed in"| CXCL9
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| CXCL9
    ALZHEIMER["ALZHEIMER"] -->|"expressed in"| CXCL9
    CXCL1["CXCL1"] -->|"inhibits"| CXCL9
    AXL["AXL"] -->|"inhibits"| CXCL9
    BAX["BAX"] -->|"activates"| CXCL9
    IL32["IL32"] -->|"activates"| CXCL9
    APOPTOSIS["APOPTOSIS"] -->|"activates"| CXCL9

Outgoing (77)

Target	Relation	Type	Str
h-caf71f08b9	associated_with	hypothesis	1.00
Th1-Type Response	involved_in	process	0.85
Neuroinflammation	associated_with	process	0.85
T Cell Infiltration	correlates_with	process	0.85
Inflammation	activates	disease	0.75
Multiple Sclerosis	associated_with	disease	0.75
Alzheimer's Disease	associated_with	disease	0.75
CXCR3	interacts_with	protein	0.72
macrophages	expressed_in	cell_type	0.70
Inflammation	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Encephalitis	expressed_in	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Lymphoma	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Psoriasis	activates	disease	0.65
ALS	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Als	activates	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	associated_with	disease	0.65
AXL	inhibits	gene	0.60
CXCL1	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
STAT1	activates	gene	0.60
SPP1	activates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
MMP12	biomarker_for	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
Immune Response	activates	pathway	0.60
CXCR3	associated_with	gene	0.60
multiple sclerosis	associated_with	disease	0.60
Alzheimer's disease	associated_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
CXCR3	expressed_in	gene	0.60
IFN	associated_with	gene	0.60
PD1	expressed_in	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CXCL10	associated_with	gene	0.60
Interferon	associated_with	protein	0.60
Chemokine	associated_with	protein	0.60
Cytokine	associated_with	protein	0.60
Rb	associated_with	protein	0.60
T cells	expressed_in	cell_type	0.60
CXCL11	associated_with	gene	0.60

Incoming (49)

Source	Relation	Type	Str
h-caf71f08b9	targets	hypothesis	1.00
IFNG	upregulates	protein	0.90
IFN_GAMMA	activates	protein	0.64
CD8	activates	gene	0.60
TREM2	regulates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
CXCL10	inhibits	gene	0.60
CXCL1	biomarker_for	gene	0.60
CXCL10	biomarker_for	gene	0.60
IL-6	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
TNF	activates	gene	0.60
DAPK1	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
RIPK3	activates	gene	0.60
CCL2	activates	gene	0.60
BAX	activates	gene	0.60
CXCL11	activates	gene	0.60
CXCL10	activates	gene	0.60
CHIT1	inhibits	gene	0.60
CXCL10	associated_with	gene	0.60
CXCL11	associated_with	gene	0.60
GENES	activates	gene	0.60
IL32	activates	gene	0.60
CXCR3	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
IFN	associated_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
CXCL1	inhibits	gene	0.60
AXL	inhibits	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CXCL10	interacts_with	gene	0.60
CCR2	expressed_in	gene	0.60
CD8	expressed_in	gene	0.60
AND	activates	gene	0.60
Neuroinflammation	associated_with	process	0.50
Neurodegeneration	associated_with	disease	0.50
CXCR3	associated_with	gene	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
MULTIPLE SCLEROSIS	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
CXCL10	causes	gene	0.50
MMP12	inhibits	gene	0.50
IL-8	inhibits	protein	0.50
inflammation	inhibits	pathway	0.50
H4	associated_with	hypothesis	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

closed · Rounds: 4 · Score: 0.82 · 2026-04-22

Related Research

Hypotheses and analyses mentioning CXCL9 in their description or question text

No additional research found