gene

IL32

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL32: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

15Outgoing

1Incoming

0Experiments

0Debates

Summary

IL32 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Inflammation, Psoriasis. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL32
Chromosome	16p13.3
Function	is a pro-inflammatory cytokine originally identified based on its elevated expression in activated natural killer (NK) cells and T cells [1/https://pubmed.
Primary Expression	various cell types including T cells, NK cells, monocytes, epithelial cells, and endothelial cells
Pathways	Apoptosis, Necroptosis
Ensembl ID	ENSG00000127124
GeneCards	IL32
Human Protein Atlas	IL32
Associated Diseases	neurodegeneration
Interactions	APOPTOSIS, BAX, CCL2, CXCL10, CXCL11, CXCL9
KG Connections	16 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL32

gene · 3130 words

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Pathway Diagram

graph TD
    IL32["IL32"]
    Inflammation{"Inflammation"}
    IL32 -->|"activates"| Inflammation
    Psoriasis{"Psoriasis"}
    IL32 -->|"activates"| Psoriasis
    APOPTOSIS["APOPTOSIS"]
    IL32 -->|"activates"| APOPTOSIS
    TNF["TNF"]
    IL32 -->|"activates"| TNF
    DAPK1["DAPK1"]
    IL32 -->|"activates"| DAPK1
    INFLAMMATION["INFLAMMATION"]
    IL32 -->|"activates"| INFLAMMATION
    RIPK3["RIPK3"]
    IL32 -->|"activates"| RIPK3
    CCL2["CCL2"]
    IL32 -->|"activates"| CCL2
    GENES["GENES"]
    IL32 -->|"activates"| GENES
    CXCL11["CXCL11"]
    IL32 -->|"activates"| CXCL11
    CXCL10["CXCL10"]
    IL32 -->|"activates"| CXCL10
    CXCL9["CXCL9"]
    IL32 -->|"activates"| CXCL9
    IFN["IFN"]
    IL32 -->|"activates"| IFN
    Apoptosis(["Apoptosis"])
    IL32 -->|"activates"| Apoptosis
    Necroptosis(["Necroptosis"])
    IL32 -->|"activates"| Necroptosis

Outgoing (15)

Target	Relation	Type	Str
Inflammation	activates	disease	0.65
Psoriasis	activates	disease	0.65
CCL2	activates	gene	0.60
GENES	activates	gene	0.60
CXCL11	activates	gene	0.60
CXCL9	activates	gene	0.60
IFN	activates	gene	0.60
Apoptosis	activates	pathway	0.60
APOPTOSIS	activates	gene	0.60
Necroptosis	activates	pathway	0.60
INFLAMMATION	activates	gene	0.60
TNF	activates	gene	0.60
DAPK1	activates	gene	0.60
RIPK3	activates	gene	0.60
CXCL10	activates	gene	0.60

Incoming (1)

Source	Relation	Type	Str
BAX	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL32 in their description or question text

No additional research found