protein

IL-8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

1Analyses

24Outgoing

31Incoming

0Experiments

1Debates

Summary

Page for IL-8 Protein

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🔬 Protein Info

Gene Symbol	IL
Function	Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation.
GeneCards	IL
Human Protein Atlas	IL
Associated Diseases	CRC
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

IL-8 Protein

protein · 754 words

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Pathway Diagram

graph TD
    IL_8["IL-8"]
    PLCB3["PLCB3"]
    PLCB3 -->|"regulates"| IL_8
    IL17C["IL17C"]
    IL17C -->|"upregulates"| IL_8
    TERC["TERC"]
    IL_8 -->|"activates"| TERC
    CYTOKINES["CYTOKINES"]
    IL_8 -->|"activates"| CYTOKINES
    Telomere["Telomere"]
    IL_8 -->|"activates"| Telomere
    MONOCYTE["MONOCYTE"]
    IL_8 -->|"activates"| MONOCYTE
    Telomere["Telomere"]
    IL_8 -->|"regulates"| Telomere
    TERC["TERC"]
    IL_8 -->|"associated with"| TERC
    CYTOKINES["CYTOKINES"]
    IL_8 -->|"associated with"| CYTOKINES
    Telomere["Telomere"]
    IL_8 -->|"associated with"| Telomere
    inflammation["inflammation"]
    IL_8 -->|"inhibits"| inflammation
    INNATE_IMMUNITY["INNATE IMMUNITY"]
    IL_8 -->|"inhibits"| INNATE_IMMUNITY
    CXCL9["CXCL9"]
    IL_8 -->|"inhibits"| CXCL9
    TUMOR["TUMOR"]
    IL_8 -->|"activates"| TUMOR
    Mitochondrial_Function["Mitochondrial Function"]
    IL_8 -->|"activates"| Mitochondrial_Function
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    IL_8 -->|"activates"| Reactive_Oxygen_Species
    Proteins["Proteins"]
    IL_8 -->|"activates"| Proteins
    oxidative_stress["oxidative stress"]
    IL_8 -->|"activates"| oxidative_stress
    Synaptic_Plasticity["Synaptic Plasticity"]
    IL_8 -->|"activates"| Synaptic_Plasticity
    Neuroprotection["Neuroprotection"]
    IL_8 -->|"activates"| Neuroprotection
    IGF_1["IGF-1"]
    IL_8 -->|"activates"| IGF_1
    I_B_["IKappaBAlpha"]
    IL_8 -->|"inhibits"| I_B_
    NF__B["NF-kappaB"]
    IL_8 -->|"inhibits"| NF__B
    IL_1_["IL-1Beta"]
    IL_1_ -->|"co discussed"| IL_8
    IL_6["IL-6"]
    IL_6 -->|"co discussed"| IL_8
    I_B_["IKappaBAlpha"]
    I_B_ -->|"inhibits"| IL_8
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| IL_8
    BDNF["BDNF"]
    BDNF -->|"protects against"| IL_8
    FGF21["FGF21"]
    FGF21 -->|"protects against"| IL_8
    GENES["GENES"]
    GENES -->|"co discussed"| IL_8

Outgoing (24)

Target	Relation	Type	Str
neuroinflammation	activates	mechanism	0.70
senescence	participates_in	pathway	0.55
microglia	expressed_in	cell_type	0.55
neurons	expressed_in	cell_type	0.55
inflammation	inhibits	pathway	0.50
CXCL9	inhibits	concept	0.50
TUMOR	activates	disease	0.50
Mitochondrial Function	activates	pathway	0.50
Reactive Oxygen Species	activates	process	0.50
Proteins	activates	protein	0.50
oxidative stress	activates	phenotype	0.50
Synaptic Plasticity	activates	pathway	0.50
Neuroprotection	activates	process	0.50
IGF-1	activates	concept	0.50
CYTOKINES	activates	concept	0.50
Telomere	activates	pathway	0.50
MONOCYTE	activates	concept	0.50
Telomere	regulates	pathway	0.50
TERC	activates	gene	0.50
CYTOKINES	associated_with	concept	0.50
Telomere	associated_with	pathway	0.50
IΚBΑ	inhibits	protein	0.50
NF-κB	inhibits	concept	0.50
TERC	associated_with	gene	0.50

Incoming (31)

Source	Relation	Type	Str
PLCB3	regulates	gene	0.90
PNS-R1	downregulates	compound	0.85
pulmonary vascular endothelial cell senescence	upregulates	process	0.85
IL17C	upregulates	gene	0.80
TNF	upregulates	protein	0.80
IL-6	associated_with	gene	0.55
IL-1Β	co_discussed	protein	0.50
IL-6	co_discussed	protein	0.50
IΚBΑ	inhibits	protein	0.50
ALZHEIMER	activates	gene	0.50
GENES	co_discussed	gene	0.50
HEPSIN	co_discussed	protein	0.50
CXCL1	inhibits	gene	0.50
MMP12	inhibits	gene	0.50
CXCL10	inhibits	gene	0.50
IL-6	inhibits	protein	0.50
TERT	associated_with	gene	0.50
MFN2	activates	gene	0.50
DRP1	activates	protein	0.50
OPA1	activates	protein	0.50
BDNF	activates	gene	0.50
FGF21	activates	gene	0.50
SPARC	activates	protein	0.50
IRISIN	activates	protein	0.50
IL-6	activates	protein	0.50
microglia	interacts_with	cell_type	0.50
IL-6	interacts_with	protein	0.50
BDNF	decreases_risk	gene	0.50
FGF21	decreases_risk	gene	0.50
IRISIN	decreases_risk	protein	0.50
IL-1Β	inhibits	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate identified APOE4 astrocytes as potential senescence drivers but did n

closed · Rounds: 4 · Score: 0.76 · 2026-04-22

Related Research

Hypotheses and analyses mentioning IL-8 in their description or question text

No additional research found