protein

BCL-2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCL-2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1935Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

BCL-2 is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Aging, Als. Connected to 1238 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BCL
Pathways	Leukemia Cell Survival
GeneCards	BCL
Human Protein Atlas	BCL
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/Compounds	APG-2575, dasatinib, kaempferitrin, quercetin, venetoclax, Venetoclax
Interactions	6-OHDA, ABCG2, ABL1, Actin, ADSL, AGING
KG Connections	1895 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    BCL_2["BCL-2"] -->|"promotes"| mitochondrial_outer_membrane_p["mitochondrial outer membrane permeabilization"]
    BCL_2["BCL-2"] -->|"regulates"| Fibrosis["Fibrosis"]
    BCL_2["BCL-2"] -->|"therapeutic target"| Als["Als"]
    BCL_2["BCL-2"] -->|"associated"| Lymphoma["Lymphoma"]
    BCL_2["BCL-2"] -.->|"inhibits"| Cancer["Cancer"]
    BCL_2["BCL-2"] -.->|"inhibits"| Als_1["Als"]
    DAG1["DAG1"] -->|"regulates"| BCL_2["BCL-2"]
    HSPG2["HSPG2"] -->|"regulates"| BCL_2["BCL-2"]
    FOXO1["FOXO1"] -->|"associated"| BCL_2["BCL-2"]
    BAX["BAX"] -->|"associated"| BCL_2["BCL-2"]
    style BCL_2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1117)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:BCL-2	data_in	dataset_row	0.00
BCL-2	encodes	protein	0.00
Als	activates	disease	1.00
Cancer	activates	disease	1.00
Cancer	regulates	disease	1.00
Mtor	activates	pathway	1.00
Als	associated_with	disease	1.00
Autophagy	activates	pathway	1.00
Apoptosis	therapeutic_target	pathway	1.00
MTOR	activates	gene	1.00
Als	regulates	disease	1.00
Inflammation	activates	disease	1.00
Carcinoma	therapeutic_target	disease	1.00
AUTOPHAGY	activates	gene	1.00
Tumor	therapeutic_target	disease	1.00
Leukemia	therapeutic_target	disease	1.00
Neurodegeneration	activates	disease	1.00
Apoptosis	expressed_in	pathway	1.00
Apoptosis	regulates	pathway	1.00
Lymphoma	regulates	disease	1.00
Apoptosis	activates	pathway	1.00
Tumor	activates	disease	1.00
Cancer	therapeutic_target	disease	1.00
Apoptosis	inhibits	pathway	1.00
Lymphoma	therapeutic_target	disease	1.00
Cancer	inhibits	disease	1.00
Als	inhibits	disease	1.00
Pi3K/Akt	activates	pathway	1.00
Tumor	inhibits	disease	1.00
Inflammation	inhibits	disease	1.00
Als	therapeutic_target	disease	1.00
Neuroinflammation	activates	disease	1.00
Drug Resistance	therapeutic_target	pathway	1.00
Oxidative Stress	activates	pathway	1.00
Tumor	expressed_in	disease	1.00
Pi3K/Akt	therapeutic_target	pathway	1.00
Apoptosis	associated_with	pathway	1.00
Cardiac	activates	disease	1.00
AKT	activates	gene	1.00
BRAIN INJURY	activates	gene	1.00
AKT	therapeutic_target	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
Nf-Κb	therapeutic_target	pathway	1.00
NRF2	activates	gene	1.00
P62	activates	gene	1.00
DNA	activates	gene	1.00
MITOCHONDRIA	activates	gene	1.00
Parkinson	activates	disease	0.95
Alzheimer	activates	disease	0.95
Als	expressed_in	disease	0.95

Incoming (818)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:BCL-2	data_in	dataset_row	0.00
BCL-2	encodes	gene	0.00
PI3K	activates	gene	1.00
TNF	activates	gene	1.00
BAX	inhibits	gene	1.00
PI3K	therapeutic_target	gene	1.00
AUTOPHAGY	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
TNF-Α	activates	gene	1.00
APOPTOSIS	inhibits	gene	1.00
BAX	expressed_in	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
GENES	activates	gene	1.00
BAX	regulates	gene	1.00
APOPTOSIS	regulates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
AMPK	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
CANCER	inhibits	gene	1.00
ROS	activates	gene	1.00
BAX	activates	gene	1.00
CANCER	activates	gene	1.00
APOPTOSIS	associated_with	gene	1.00
GENES	inhibits	gene	1.00
CYTOKINES	inhibits	gene	1.00
APOPTOSIS	expressed_in	gene	1.00
NEURODEGENERATIVE DISEASES	activates	gene	1.00
CANCER	regulates	gene	1.00
STAT3	activates	gene	1.00
HO-1	activates	gene	1.00
venetoclax	inhibits	drug	0.95
T3	upregulates	drug	0.95
Venetoclax	inhibits	drug	0.95
Venetoclax	targets	drug	0.90
TP53	binds_to	protein	0.90
ASTROCYTES	activates	gene	0.90
TNF	inhibits	gene	0.90
NF-ΚB	therapeutic_target	gene	0.90
PI3K	regulates	gene	0.90
GENES	therapeutic_target	gene	0.90
PI3K	associated_with	gene	0.90
P53	inhibits	gene	0.90
P53	expressed_in	gene	0.90
GENES	expressed_in	gene	0.90
ROS	regulates	gene	0.90
BCL2	activates	gene	0.90
PARKINSON'S DISEASE	activates	gene	0.90
PI3K	inhibits	gene	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BCL-2 in their description or question text

No additional research found